{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:46:09Z","timestamp":1773787569153,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":328,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emergency Medicine International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Diagnosis of multisystem inflammatory syndrome in children (MIS\u2010C) is challenging due to symptom overlap with other common conditions. The primary objective of this multicenter study was to establish normative laboratory values in MIS\u2010C patients and compare to patients evaluated for MIS\u2010C who had other final diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Five hospitals reviewed records of a cohort of patients 6\u2009months to 18\u2009years old who were evaluated for MIS\u2010C between March 31\n                      <jats:sup>st<\/jats:sup>\n                      2020 and February 1\n                      <jats:sup>st<\/jats:sup>\n                      2022. Patient demographics, clinical presentation, and laboratory values were compared in patients with a final diagnosis of MIS\u2010C versus all other conditions. Patients\u2019 final diagnoses and laboratory values for each diagnosis were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 1319 patients that were evaluated for MIS\u2010C at presentation, 293 (22.2%) received a final diagnosis of MIS\u2010C. MIS\u2010C patients had statistically significant differences in laboratory values including D\u2010dimer, ferritin, fibrinogen, troponin, and brain natriuretic peptide when compared to patients evaluated for MIS\u2010C but subsequently diagnosed with other conditions. The most common non\u2010MIS\u2010C diagnoses within this cohort were viral illnesses (26.7%), acute COVID\u201019 (12.0%), pyelonephritis (6.4%), fever of unknown origin (4.9%), pneumonia (4.7%), gastroenteritis (4.7%), Kawasaki disease (3.7%), other bacterial infections, (3.1%), rheumatologic conditions (3.1%), and sepsis (2.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Many patients who underwent laboratory evaluation for MIS\u2010C during the COVID\u201019 pandemic received a final diagnosis other than MIS\u2010C. These data may aid pediatricians in differentiating between MIS\u2010C and other febrile conditions as well as reduce unnecessary testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/emmi\/2660909","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T08:22:08Z","timestamp":1764058928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Normative Laboratory Value Ranges in Pediatric Patients Who Underwent Evaluation for MIS\u2010C"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5624-8373","authenticated-orcid":false,"given":"Thomas","family":"Graf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-691X","authenticated-orcid":false,"given":"Nathan 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