{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:03:53Z","timestamp":1784541833518,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":200,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Emergency Medicine International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Albumin, the most abundant blood protein, is widely used as a plasma expander in critically ill patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of albumin compared to other alternatives in the prevention and treatment of complications in critically ill adults, considering different comparators and clinical situations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review was conducted, including randomized controlled trials (RCTs) comparing albumin with crystalloids, other colloids, or standard care without albumin. Primary outcomes were total mortality, blood transfusion requirement, and serious adverse events. The search was performed in MEDLINE, Embase, and Cochrane Central. Meta\u2010analysis was conducted using the Mantel\u2013Haenszel method with a random\u2010effects model, and heterogeneity was assessed with the I\n                      <jats:sup>2<\/jats:sup>\n                      statistic. The risk of bias was evaluated using Cochrane RevMan 5.4, and the quality of evidence was assessed with the GRADE approach.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010five RCTs involving 13,975 critically ill adults were included. Mortality was 23.8% (1327\/5586) with albumin and 24.2% (1361\/5618). Compared with colloids, mortality was 21.9% (83\/379) versus 24.4% (113\/463). When compared with standard care without albumin, mortality was higher with albumin: 15.8% (60\/380) versus 9.2% (39\/424). SAEs occurred in 37.6% (298\/793) of albumin\u2010treated patients versus 33.5% (266\/793) with crystalloids. Albumin required less transfused blood volume than colloids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Albumin showed no benefit over crystalloids, colloids, or standard care without albumin in reducing mortality. It resulted in less blood transfusions compared to colloids, but serious adverse events were higher than with crystalloids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/emmi\/7434218","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:20:21Z","timestamp":1784539221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Albumin in Critically Ill Adults: A Systematic Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-2813","authenticated-orcid":false,"given":"Tal\u00eda Gabriela Porras","family":"Su\u00e1rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3229-6614","authenticated-orcid":false,"given":"Marta Guti\u00e9rrez","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9143-5709","authenticated-orcid":false,"given":"Luis Carlos","family":"Saiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8837-1277","authenticated-orcid":false,"given":"Juan Pedro Tirapu","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitor Ansotegui","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2945-7955","authenticated-orcid":false,"given":"Amaia Eg\u00fc\u00e9s","family":"Lugea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-7086","authenticated-orcid":false,"given":"Leire Leache","family":"Alegr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-2102","authenticated-orcid":false,"given":"Juan","family":"Erviti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.06.006"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2018.1412827"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.04.019"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04154-2"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-012-0802-0"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2013.05.015"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000341"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2020.07.005"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2020.1840970"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000567.pub7"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"e_1_2_11_12_2","article-title":"Users\u2019 Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice","volume":"90","author":"Graves R. S.","year":"2002","journal-title":"Journal of the Medical Library Association"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_11_14_2","volume-title":"ICH E2A: Clinical Safety Data Management: Definitions and Standards for Expedited Reporting [Internet]","author":"European Medicines Agency","year":"1995"},{"key":"e_1_2_11_15_2","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5 (Updated August 2024)","author":"Higgins J. P. T.","year":"2024"},{"key":"e_1_2_11_16_2","article-title":"Version (5.4)","author":"Review Manager (RevMan)","year":"2011","journal-title":"The Cochrane Collaboration"},{"key":"e_1_2_11_17_2","article-title":"GRADE Handbook","author":"Schumemann H.","year":"2013","journal-title":"Grading of Recommendations Assessment, Development and Evaluation"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209759"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00679-3"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030276"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2024.01.016"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2014.12.007"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2013.03.007"},{"key":"e_1_2_11_24_2","article-title":"Navarrese Health Service, MAPAC","author":"Guti\u00e9rrez M.","journal-title":"Albumin evaluation report"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redar.2014.04.016"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.30445\/rear.v9i8.147"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/08850666231170778"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0145-5"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.54095\/bitn20233103"},{"key":"e_1_2_11_30_2","doi-asserted-by":"crossref","unstructured":"CallumJ. SkubasN. J. BathlaA.et al. International Collaboration for Transfusion Medicine Guidelines Intravenous Albumin Guideline Group. Use of Intravenous Albumin: A Guideline from the International Collaboration for Transfusion Medicine Guidelines Chest https:\/\/doi.org\/10.1016\/j.chest.2024.02.049.","DOI":"10.1016\/j.chest.2024.02.049"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.07.013"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181ffe217"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000567.pub6"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000002039"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12185919"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/17511437241259437"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-03035-y"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-02925-5"}],"container-title":["Emergency Medicine International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/emmi\/7434218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/emmi\/7434218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/emmi\/7434218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:20:24Z","timestamp":1784539224000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/emmi\/7434218"}},"subtitle":[],"editor":[{"given":"Shashank","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/emmi\/7434218"],"URL":"https:\/\/doi.org\/10.1155\/emmi\/7434218","archive":["Portico"],"relation":{},"ISSN":["2090-2840","2090-2859"],"issn-type":[{"value":"2090-2840","type":"print"},{"value":"2090-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7434218"}}