{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:58:40Z","timestamp":1785394720289,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":209,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetics Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>This study examined whether circulating lipid traits and lipid\u2010lowering drug targets are causally associated with intervertebral disc degeneration (IVDD) using a Mendelian randomization (MR) framework. We analyzed summary\u2010level data from genome\u2010wide association studies (GWASs) covering apolipoproteins, lipid parameters, and IVDD. Univariable analysis revealed that inherently elevated high\u2010density lipoprotein cholesterol (HDL\u2010C) correlated with reduced IVDD susceptibility. By contrast, low\u2010density lipoprotein cholesterol (LDL\u2010C), triglycerides (TGs), apolipoprotein A\u2010I (Apoa\u2010I), and apolipoprotein B (Apob) did not remain significant after Bonferroni correction. Upon adjusting for body mass index (BMI) in a multivariable framework, the protective link between HDL\u2010C and IVDD held strong, whereas LDL\u2010C, TG, and Apob remained nonsignificant. Summary data\u2013based MR and drug\u2013target MR analyses further suggested a significant association between NPC1L1 gene expression and IVDD susceptibility. Overall, these results highlight the potential involvement of lipid pathways in disc degeneration and justify further biological and clinical investigation.<\/jats:p>","DOI":"10.1155\/genr\/5378960","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:08:57Z","timestamp":1785391737000},"source":"Crossref","is-referenced-by-count":0,"title":["Lipids and Lipid\u2010Lowering Drugs With Risk of Intervertebral Disc Degeneration: A Mendelian Randomization 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