{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:07:14Z","timestamp":1779271634800,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":139,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["25ZR1401326"],"award-info":[{"award-number":["25ZR1401326"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["23YF1441400"],"award-info":[{"award-number":["23YF1441400"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetics Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteoporosis (OP) and its associated complications have emerged as critical public health challenges worldwide, primarily due to the high rates of disability and mortality they cause. In terms of its complex pathogenesis, epigenetic mechanisms play significant roles. Against this backdrop, this study aims to clarify the current research trends and hotspots in OP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Literature was retrieved from the \u201cWeb of Science,\u201d \u201cPubMed,\u201d and \u201cScopus.\u201d Subsequently, publication counts, country distribution, regional collaborations, and keyword analyses were conducted by using the \u201cBibliometrix\u201d and \u201cggplot2\u201d packages in\n                      <jats:italic>R<\/jats:italic>\n                      Studio. For visualization analysis, institutional cooperation and keyword relationships were examined using \u201cCiteSpace\u201d and \u201cVOSviewer.\u201d\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 464 publications were included in this analysis. The five most frequently cited keywords were \u201cpostmenopausal osteoporosis (PMOP),\u201d \u201cexpression,\u201d \u201cmesenchymal stem\u2010cells (MSCs),\u201d \u201costeogenic differentiation,\u201d and \u201cdifferentiation.\u201d Keyword co\u2010occurrence analysis further identified \u201cexpression,\u201d \u201cPMOP,\u201d and \u201cMSCs\u201d as predominant research themes. Moving forward, the findings suggest that future research will focus on elucidating the role of miRNAs in the epigenetic mechanisms of OP and identifying potential therapeutic targets. Regarding global collaboration, China led in international partnerships, particularly with the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Epigenetic mechanisms constitute a core regulatory factor in OP, serving as the critical link between genetic predisposition and environmental influences. Emerging research emphasizes the combined analysis of epigenetics and metabolomics, artificial intelligence (AI)\u2013based prediction of epigenetic regulatory networks, and gene editing therapies targeting epigenetic factors. Furthermore, therapeutic strategies\u2014including gene therapy, stem cell\u2013based interventions, and small\u2010molecule targeted compounds\u2014represent pivotal future directions for OP therapeutics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/genr\/7389868","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:22:53Z","timestamp":1779268973000},"source":"Crossref","is-referenced-by-count":0,"title":["Research Hotspots and Emerging Trends in Osteoporosis Epigenetics"],"prefix":"10.1155","volume":"2026","author":[{"given":"Maobin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongze","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9923-4326","authenticated-orcid":false,"given":"Feng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8572-3643","authenticated-orcid":false,"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2019.07.007"},{"key":"e_1_2_12_2_2","volume-title":"StatPearls","author":"Keen M. U.","year":"2025"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115772"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c06483"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.619301"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2023.12.002"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43465-025-01414-5"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci77716"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404518"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2024.08.005"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102235"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12794"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-024-01057-y"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.02.090"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2478323"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12688"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.20-0308"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70344"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006522"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045142"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.08.018"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16003"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12064"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2032"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09550-1"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034641"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.21106"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2365"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2025.04.019"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175073"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103168"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.70010"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.49079"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-025-05798-w"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-025-08505-2"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19360-1"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-021-10031-z"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2423991122"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2024.100501"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2019.151422"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02472-2"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4327"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1481322"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01085-y"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-025-05684-y"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c01619"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.20517\/2347-9264.2022.72"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-024-03449-7"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2025.101026"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0773-z"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.109302"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01309-7"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.3300"}],"container-title":["Genetics Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/genr\/7389868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/genr\/7389868","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/genr\/7389868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:22:55Z","timestamp":1779268975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/genr\/7389868"}},"subtitle":[],"editor":[{"given":"xiaoye","family":"jin","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/genr\/7389868"],"URL":"https:\/\/doi.org\/10.1155\/genr\/7389868","archive":["Portico"],"relation":{},"ISSN":["0016-6723","1469-5073"],"issn-type":[{"value":"0016-6723","type":"print"},{"value":"1469-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"7389868"}}