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This narrative review examines cholera outbreaks in Nigeria, exploring epidemiological trends, socioeconomic and meteorological drivers, and advancements in diagnostic technologies. Emphasis is placed on the role of artificial intelligence (AI) in transforming cholera management through predictive modeling, early detection, and resource optimization. Rapid diagnostic tests (RDTs), molecular diagnostics, and biosensors are highlighted as tools for enhancing surveillance and improving outbreak response. Despite these advancements, Nigeria faces significant challenges, including inadequate laboratory infrastructure, insufficient environmental monitoring, and limited access to diagnostic tools in rural areas. Recommendations include strengthening diagnostic capacity, integrating AI\u2010driven tools, and implementing proactive environmental surveillance. The manuscript underscores the importance of coordinated efforts among federal and state health agencies, international partners, and local communities to address the persistent cholera burden. By leveraging these strategies, Nigeria can improve its outbreak preparedness and mitigate the morbidity and mortality associated with cholera. This review provides actionable insights for public health interventions and policy\u2010making, offering a forward\u2010looking perspective on combating cholera through innovation and collaboration.<\/jats:p>","DOI":"10.1155\/ghe3\/8898076","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T06:03:47Z","timestamp":1748412227000},"source":"Crossref","is-referenced-by-count":8,"title":["Cholera Outbreak in Nigeria: History, Review of Socioeconomic and Meteorological Drivers, Diagnostic Challenges, and Artificial Intelligence Integration"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7245-0340","authenticated-orcid":false,"given":"Adewunmi","family":"Akingbola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-5360","authenticated-orcid":false,"given":"Adegbesan","family":"Abiodun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6794-0085","authenticated-orcid":false,"given":"Olajide","family":"Ojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5877-3233","authenticated-orcid":false,"given":"Otumara Urowoli","family":"Jessica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6501-2067","authenticated-orcid":false,"given":"Uthman Hassan","family":"Alao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Omolayo","family":"Owolabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8685-0074","authenticated-orcid":false,"given":"Joel","family":"Chuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_2_17_1_2","unstructured":"Cholera-Global Situation 2024 https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2022-DON426."},{"key":"e_1_2_17_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed6030147"},{"key":"e_1_2_17_3_2","doi-asserted-by":"crossref","unstructured":"Global Patterns of Trends in Cholera Mortality https:\/\/www.mdpi.com\/2414-6366\/8\/3\/169.","DOI":"10.3390\/tropicalmed8030169"},{"key":"e_1_2_17_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2024.109210"},{"key":"e_1_2_17_5_2","unstructured":"The Surging Cholera Epidemic in Africa: A Review of the Current Epidemiology Challenges and Strategies for Control https:\/\/ouci.dntb.gov.ua\/en\/works\/7AKYoYJl\/."},{"key":"e_1_2_17_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)33050-7"},{"key":"e_1_2_17_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/11786329231211964"},{"key":"e_1_2_17_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-044615"},{"key":"e_1_2_17_9_2","article-title":"REVIEW PAPER-Cholera in Nigeria: Epidemiology, Risk Factors, and Response-A Review","volume":"14","author":"Salako Bolaji L.","year":"2021","journal-title":"Proc Niger Acad Sci [Internet]"},{"key":"e_1_2_17_10_2","unstructured":"Cholera Outbreak in a Na\u00efve Rural Community in Northern Nigeria: the Importance of Hand Washing with Soap September 2010 https:\/\/pubmed.ncbi.nlm.nih.gov\/30123408\/."},{"key":"e_1_2_17_11_2","first-page":"7","article-title":"Investigation of Cholera Outbreak in an Urban North Central Nigerian Community-The Akwanga Experience","volume":"4","author":"A A. 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