{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:07:40Z","timestamp":1792001260320,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":106,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Global Health, Epidemiology and Genomics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Antibiotic resistance is a growing global health crisis that complicates the treatment of urinary tract infections (UTIs). While Enterobacterales are primary UTI pathogens, nonenteric pathogens such as\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic>Burkholderia cepacia<\/jats:italic>\n                    , and\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    spp. are increasingly recognized, posing challenges due to their complex resistance mechanisms. This study aims to investigate the prevalence, resistance patterns, and multidrug resistance (MDR) of nonenteric pathogens in community\u2010acquired UTIs in Albania.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods:<\/jats:bold>\n                    The study was conducted in an outpatient clinic from September 2023 to September 2024, involving adults (\u2265 18\u2009years) and excluding individuals with recent antibiotic use or pregnancy. Urine samples were processed using blood and MacConkey Agar, followed by bacterial identification and susceptibility testing with the VITEK 2 system. A total of 11 antibiotics belonging to\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010lactams, fluoroquinolones, glycylcyclines, oxazolidinones, lipopeptides, glycopeptides, and tetracyclines were tested. Statistical analysis was performed using SPSS, with significance set at\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 550 urine cultures were analyzed, of which 372 (67.6%) were positive for bacterial growth. Among these, 27.7% were identified as nonenteric pathogens, with a higher occurrence in females (66%) and young adults (18\u201339\u2009years) (60.2%).\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    was the most common Gram\u2010positive pathogen (15.2% of the positive samples), while\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    was the most frequent Gram\u2010negative pathogen (9.1%).\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    showed significant resistance to tigecycline (91.2%) and levofloxacin (38.2%), with no resistance to meropenem.\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    showed high resistance to vancomycin (53.6%) and teicoplanin (46.4%), while\n                    <jats:italic>S. saprophyticus<\/jats:italic>\n                    showed moderate resistance. MDR prevalence was highest in\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    (26.5%).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    This study highlights the high prevalence of community\u2010acquired UTIs in Albania, particularly among females, and concerning MDR rates. To address these challenges, it is crucial to implement standardized treatment protocols, improve antibiotic stewardship, and promote research to track resistance patterns, ultimately enhancing patient care and combating antibiotic resistance.\n                  <\/jats:p>","DOI":"10.1155\/ghe3\/9944598","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T07:39:16Z","timestamp":1744875556000},"source":"Crossref","is-referenced-by-count":1,"title":["Nonenteric Pathogens in Urinary Tract Infections: Epidemiology and Resistance Patterns in Albania"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-0799","authenticated-orcid":false,"given":"Silvi","family":"Bozo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irida 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