{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:36:10Z","timestamp":1783366570195,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":137,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This randomized controlled trial aimed to evaluate the effects of Gui\u2010Shao San umbilical moxibustion on symptoms of the disease, psychological well\u2010being, and quality of life in patients with IBS\u2010D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>The patients were randomly assigned to three groups: One received Gui\u2010Shao San umbilical moxibustion alongside conventional Western medicine treatment; one received placebo umbilical moxibustion alongside conventional Western medicine treatment; and one received only conventional Western medicine treatment for use as a positive control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>The primary outcome measures included TCM clinical symptom score, IBS\u2010SSS, and grading criteria for TCM syndrome scores. Secondary outcome measures included SAS, SDS, and IBS\u2010QOL. The effects of the intervention on these outcomes were measured at three time points: baseline (T0), Week 2 (T1), and Week 4 (T2). At Week 8, the recurrence of patients was measured based on whether their IBS\u2010SSS score increased by one grade<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 4 weeks of treatment, compared with the positive drug control group, both the Gui\u2010Shao San umbilical moxibustion group and the placebo umbilical moxibustion group effectively relieved patients\u2032 symptoms, anxiety, and depression, while improving their quality of life. Significant differences were observed between groups in IBS\u2010SSS scores (120.61 \u00b1 30.61 vs. 128.13 \u00b1 41.85 vs. 161.82 \u00b1 59.87,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and TCM syndrome scores (7.88 \u00b1 1.709 vs. 8.59 \u00b1 2.722 vs. 9.97 \u00b1 2.099,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gui\u2010Shao San umbilical moxibustion is an effective method for treating IBS\u2010D. Further rigorous, large\u2010scale, long\u2010term trials are needed to evaluate the therapeutic effects of Gui\u2010Shao San umbilical moxibustion, focusing on interdisciplinary collaboration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The International Traditional Medicine Clinical Trial Registry (ITMCTR) Reg. No.: ITMCTR2025001072<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/grp\/1832176","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:50:17Z","timestamp":1779097817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gui\u2010Shao San Umbilical Moxibustion for Diarrhea\u2010Predominant Irritable Bowel Syndrome With Liver Depression and Spleen Deficiency Pattern: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5782-5125","authenticated-orcid":false,"given":"Mengyan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1729-8258","authenticated-orcid":false,"given":"Longshu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junquan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentao","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0365-4731","authenticated-orcid":false,"given":"Xixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-01163-3"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.021"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30217-X"},{"key":"e_1_2_13_5_2","first-page":"18","article-title":"A Study on the Relationship Between the Distribution of Major Symptoms and Different Factors in 360 Cases of Diarrhoeal Irritable Bowel Syndrome","volume":"17","author":"Wang H. 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