{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:15:25Z","timestamp":1772993725592,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background and Aims:<\/jats:bold>\n                    The pandemic of coronavirus disease 2019 (COVID\u201019) had a major impact on the health of people worldwide, including the pediatric inflammatory bowel disease (PIBD) patients. As no study has investigated the susceptibility and disease course of COVID\u201019 in PIBD patients after the end of zero\u2010COVID policy in China, we conducted a retrospective cross\u2010sectional study in our center.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A cross\u2010sectional survey enrolling PIBD patients has been completed by online survey, phone, and face\u2010to\u2010face assessment. The demographic data, epidemiological characteristics, clinical manifestations, treatment, and prognosis of the patients were analyzed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    PIBD patients represented 55.45% (56\/101) of SARS\u2010CoV\u20102\u2010positive cases between December 1st 2022 and January 31st 2023; 67.86% were male; the mean age was 11.15 \u00b1 3.92 years old. Among the SARS\u2010CoV\u20102\u2010positive cases, three patients (5.36%) were asymptomatic, and 53 patients (94.64%) had mild symptoms. The main symptoms were fever (92.86%), cough (69.64%), nasal congestion or running nose (35.71%), and sore throat (33.93%). No severe case or deaths were reported. All patients recovered from COVID\u201019 symptoms within 1 week. We found no significant association between the type of inflammatory bowel disease (IBD) (Crohn\u2019s disease, ulcerative colitis, and unclassified) and SARS\u2010CoV\u20102 infection rates, nor did we observe any correlation between different treatments and the risk of infection. Fifty\u2010one patients were reported to be in close contact with persons confirmed with COVID\u201019 infection, and out of them, 36 patients test positive for SARS\u2010CoV\u20102, which is significantly higher than that in patients without exposure to COVID\u201019 (70.59% vs. 33.33%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). A total of 10 patients were underweight, of which nine patients tested positive for COVID\u201019 (90% vs. 51.65%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.048). Meanwhile, unvaccinated patients were also found to be more susceptible to SARS\u2010CoV\u20102 than vaccinated patients (70.97% vs. 48.48%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.049). The multivariable analysis showed that patients with moderate\/severe activity of IBD were associated with an increased risk of SARS\u2010CoV\u20102 infection (odds ratio (OR), 1.12; 95% confidence interval (CI), 1.13\u20138.33,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.028).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The incidence of SARS\u2010CoV\u20102 infection in our center of PIBD patients during the Omicron pandemic was 55.45%. No severity or death case was observed. The incidence was higher in underweight and unvaccinated IBD children. Patients with moderate\/severe activity of IBD were at a higher risk of SARS\u2010CoV\u20102 infection.\n                  <\/jats:p>","DOI":"10.1155\/grp\/1868214","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T07:19:54Z","timestamp":1737011994000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Incidence and Clinical Characteristics of COVID\u201019 in Children With IBD During the Omicron Wave: A Single\u2010Center Experience in 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