{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:47:19Z","timestamp":1776754039884,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":313,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adaptation of the small intestine and\/or colon significantly impacts the prognosis of short bowel syndrome. This study investigated colonic adaptation in a mouse model of ileal resection, with a focus on bile acid absorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The ileal resection mouse model (ileal resection group, 8\u201310\u2010week\u2010old male C57BL\/6J mice) was created by resecting 15\u2009cm of the ileum, corresponding to approximately 50% of the small intestine, while preserving the cecum. The sham group underwent intestinal transection and reanastomosis at a site matched in distance from the ligament of Treitz to that used for the resection group. Postoperatively, between Days 1\u20137 and 7\u201314, mice received the elemental diet ELENTAL\u00ae (0.5 kcal\/mL) and a standard solid diet ad libitum, respectively. The mice were euthanized on Day 14. We assessed postoperative body weight; histopathological characteristics of the colon; bile acid metabolism\u2010related gene expression, including\n                      <jats:italic>Asbt<\/jats:italic>\n                      for luminal bile acid uptake,\n                      <jats:italic>Fabp6<\/jats:italic>\n                      for cytosolic transport, Ostb for bile acid excretion into the circulation, and Fxr, the primary intracellular bile acid receptor regulating the genes; and fecal and serum bile acid concentrations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significantly lower changes in body weight and longer colon length were observed in the ileal resection group than in the sham group; however, no histological differences were observed in colonic mucosal height. Furthermore, a significantly increased\n                      <jats:italic>Asbt<\/jats:italic>\n                      expression was detected in the ileal resection group. No significant differences were observed in bile acid concentrations in the feces and serum in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest a colonic adaptation to prevent impairment of bile acid absorption following ileal resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/grp\/2664210","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:56:59Z","timestamp":1762775819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Colonic Adaptation Postileal Resection: Bile Acid Absorption in an Ileal Resection Mouse Model"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4464-4767","authenticated-orcid":false,"given":"Yudai","family":"Goto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0312-9403","authenticated-orcid":false,"given":"Kouji","family":"Masumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takato","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-3463","authenticated-orcid":false,"given":"Takashi","family":"Matsuzaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Shimano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00088.2014"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.024927"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28345"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0666-9"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00528.2001"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113520005"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026697915937"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10113"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.8.1116"},{"key":"e_1_2_12_10_2","first-page":"441","article-title":"Intestinal Adaptation Following Massive Small Bowel Resection in the Mouse","volume":"183","author":"Helmrath M. 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