{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:33:38Z","timestamp":1753882418445,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":352,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670528","81701550"],"award-info":[{"award-number":["81670528","81701550"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The prognosis of patients with liver failure (LF) depends significantly on the etiology and clinical indicators. This analysis of these basic indicators can help provide a basis for the study of predictive outcome indicators.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We collected the data from multiple centers in Southeast China, including subclasses of acute liver failure (ALF), subacute liver failure (SLF), acute\u2010on\u2010chronic liver failure (ACLF), subacute\u2010on\u2010chronic liver failure (SALF), and chronic liver failure (CLF). Multivariate logistic regression analysis was used to screen for clinical indicators of nonsurvivors. We analyzed receiver operating characteristic (ROC) curves and cutoff values to assess the prognostic criteria.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Hepatitis B virus (HBV) infection is the leading etiology of patients with LF (64.52% (411\/637)). SALF (41.36%) and CLF (32.30%) are the main subclasses of the hepatitis B virus\u2013related liver failure (HBV\u2010LF) group and the non\u2010HBV\u2013related LF group in Southeast China, respectively. Between 2018 and 2020, the incidence of HBV\u2010LF decreased significantly, ranging from 72.36% to 59.74%, and the spontaneous survival rates of patients with HBV\u2010LF were substantially lower than those of non\u2010HBV\u2010LF patients (36.43%~44.93% vs. 58.97%~63.64%). Infection and cirrhosis were the leading causes of death in both groups. The age and total bilirubin value of the nonsurvivors with HBV\u2010LF were significantly higher, and the number of days of hospitalization was significantly shorter than that of the survivors. The ages of the nonsurvivors in the non\u2010HBV\u2010LF group were significantly higher than those of the survivors. The prothrombin time\u2013international normalized ratio (PT\u2010INR) is 2.05, 1.92, or 2.11, and antithrombin III (AT III) is 24.50%, which are proposed as prognostic criteria for the HBV\u2010SALF (hepatitis B virus\u2013related subacute\u2010on\u2010chronic liver failure), non\u2010HBV\u2010SLF (non\u2010hepatitis B virus\u2013related subacute liver failure), non\u2010HBV\u2010ACLF (non\u2010hepatitis B virus\u2013related acute\u2010on\u2010chronic liver failure), and HBV\u2010ALF (hepatitis B virus\u2013related acute liver failure) subclasses, respectively.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The incidence of HBV\u2010LF is decreasing annually. AT III, as an independent prognostic criterion, has excellent discriminative ability for the outcomes of the HBV\u2010ALF subclass.<\/jats:p>","DOI":"10.1155\/grp\/5512889","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T11:03:46Z","timestamp":1734519826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Etiology and Prognostic Criteria for Liver Failure in Southeast China: A Multicenter Retrospective Cohort Study Between 2018 and 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