{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:21:52Z","timestamp":1775060512026,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Late\u2010onset ulcerative colitis (UC) has become prevalent in recent years. The differences between late\u2010onset, middle aged\u2013onset, and early\u2010onset UC have not been fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical characteristics, steroid side effects, remission rates, and surgical rates of UC patients were retrospectively studied. Patients were allocated to three groups according to age at diagnosis: late\u2010onset group (\u2265\u200965 years), middle aged\u2013onset (50\u201364 years), and early\u2010onset group (\u2264\u200949 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical characteristics such as admission age, duration of disease, history of cancer, days to diagnosis, clinical activity on admission, hemoglobin level on admission, and steroid use were significantly different between the three groups. The side effects of steroids were significantly more common in the late\u2010onset group. The remission induction rates differed significantly between the three groups: 67.7%, 71.7%, and 83.6% in the late\u2010onset, middle aged\u2013onset, and early\u2010onset groups. Surgery rates were significantly higher in the late\u2010onset group: Surgery rates in the late\u2010onset, middle aged\u2013onset, and early\u2010onset groups were 14.2%, 3.4%, and 3.4% at 12 months of diagnosis, and 23.8%, 10.3%, and 4.2% at 24 months of diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, remission rates were low and surgical rates were higher with increasing age of onset. In addition, steroid\u2010related side effects increased with age. It was possible that late\u2010onset UC may have a different pathogenesis and be resistant to treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/grp\/8860301","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:34:07Z","timestamp":1769513647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Late\u2010Onset (\u2265\u200965 Years) Ulcerative Colitis: A Single\u2010Center Retrospective 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