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In plain language, clinically translatable variant biomarkers are genetic findings that can change diagnosis, family screening, surveillance intensity, or prophylactic surgical timing. We performed a cross\u2010database bibliometric study to delineate the intellectual structure and thematic evolution of clinically translatable variant\u2010based biomarker research in ascending aortic aneurysm. Web of Science Core Collection, Scopus, and PubMed were queried using concept\u2010driven terms spanning thoracic\/ascending aneurysm phenotypes, genomic variation, and biomarker\/clinical translation; searches and exports were executed on January 10, 2026, for publications from 1997 to 2025. After harmonization, deduplication, and adjudicated screening of titles\/abstracts and metadata, 1346 eligible journal articles and reviews were analyzed using bibliometrix and VOSviewer to compute productivity\/impact indicators and construct co\u2010authorship, co\u2010citation, and keyword co\u2010occurrence networks with temporal overlays. The literature exhibited rapid growth (15.35% annual growth rate) across 478 sources, with a mean of 8.94 co\u2010authors per document, 24.67% international co\u2010authorship, an average article age of 9.28 years, and 30.68 citations per article. The United States was the dominant hub (405 articles and 17,383 citations), with a densely connected Western European cluster and accelerating output from China (155 articles) but lower citation intensity. Conceptual cores were anchored in syndromic and heritable thoracic aortic disease genetics (e.g., Marfan and Loeys\u2013Dietz syndromes; FBN1 and TGF\u2010beta signaling), increasingly linked to diagnosis, variant interpretation, risk stratification, guidelines, and management. Life cycle modeling suggested an approach to publication peak around 2028, implying a shift from gene discovery toward variant interpretation, implementation, and equity\u2010conscious validation. Notably, peripheral participation from low\u2010resource regions remained sparse overall.<\/jats:p>","DOI":"10.1155\/humu\/3155191","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:55:21Z","timestamp":1779706521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinically Translatable Mutation\u2010Based Biomarkers in Ascending Aortic Aneurysm: A Bibliometric Study"],"prefix":"10.1155","volume":"2026","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-9915","authenticated-orcid":false,"given":"Xiaojun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-328X","authenticated-orcid":false,"given":"Qi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9549-686X","authenticated-orcid":false,"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.21037\/qims-21-55"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.08.004"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.09.022"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivaf125"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.036896"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.089"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065406"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.028625"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-020-01124-7"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-024-01423-3"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.121.003178"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2022.02.003"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ro.2022.07.004"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.03.367"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezad426"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbusres.2021.04.070"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbusres.2024.114760"},{"key":"e_1_2_11_18_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/0194262X.2021.1991547","article-title":"Mapping a Discipline: A Guide to Using VOSviewer for Bibliometric and Visual Analysis","volume":"41","author":"McAllister J. 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