{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:58:34Z","timestamp":1785477514268,"version":"3.56.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":210,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Mutation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Breast cancer (BC) is one of the most common and deadly cancers affecting women worldwide. This study is aimed at investigating the association between BC risk and two single nucleotide polymorphisms (SNPs):\n                    <jats:italic>ESR1<\/jats:italic>\n                    (rs2234693) and\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    (rs6443624) in a Bangladeshi population. A case\u2010control study was conducted with 112\u2009BC patients and 124 healthy controls (HCs). Genomic DNA was extracted from peripheral blood samples, and genotyping was performed using polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP). Genotype and allele frequencies were analyzed to assess their association with BC risk. Genotype distributions for both\n                    <jats:italic>ESR1<\/jats:italic>\n                    and\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    conformed to Hardy\u2013Weinberg equilibrium. The CT genotype of\n                    <jats:italic>ESR1<\/jats:italic>\n                    was associated with a reduced risk of BC, whereas the CA genotype of\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    was linked to an increased risk. The dominant model for\n                    <jats:italic>ESR1<\/jats:italic>\n                    (CT + TT vs. CC) demonstrated a significant protective effect (aOR = 0.288, 95% CI: 0.160\u20130.516), whereas the dominant model for\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    (CA + CC vs. AA) showed a higher risk (aOR = 4.166, 95% CI: 2.363\u20137.347). Over\u2010dominant models supported these findings, while recessive models for both SNPs showed no significant associations. The findings suggest that\n                    <jats:italic>ESR1 (<\/jats:italic>\n                    rs2234693) may have a protective role and\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    (rs6443624) may increase susceptibility to BC in Bangladeshi women. These SNPs may provide preliminary evidence for potential use as genetic susceptibility markers, but larger multicenter studies are needed before any clinical application can be considered.\n                  <\/jats:p>","DOI":"10.1155\/humu\/3651302","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:08:58Z","timestamp":1785474538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>ESR1<\/i>\n                    and\n                    <i>PIK3CA<\/i>\n                    Polymorphisms as Potential Genetic Susceptibility Markers for Breast Cancer Risk in Bangladeshi Women: A Case\u2010Control Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4906-2985","authenticated-orcid":false,"given":"Mahim Hassan","family":"Chowdhury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faria Billal","family":"Shaolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2656-7127","authenticated-orcid":false,"given":"Nishat Tabassum","family":"Khusbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upama Gope","family":"Puja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9391-3464","authenticated-orcid":false,"given":"Md. 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