{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:07:09Z","timestamp":1784293629228,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019217","name":"AlMaarefa University","doi-asserted-by":"publisher","award":["MHIRSP2025034"],"award-info":[{"award-number":["MHIRSP2025034"]}],"id":[{"id":"10.13039\/100019217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-2025-146"],"award-info":[{"award-number":["ORF-2025-146"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Analytical Chemistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Dasatinib, a therapy for chronic myeloid leukemia, suffers from poor bioavailability. Self\u2010microemulsifying drug delivery systems (SMEDDSs) are used to improve its dissolution. This study aimed to develop and validate a novel reverse\u2010phase high\u2010performance liquid chromatography (RP\u2010HPLC) method for quantifying dasatinib in SMEDDS formulations. The RP\u2010HPLC method utilized a mobile phase of methanol and 0.1% trifluoroacetic acid (55:45, v\/v) and identified a peak wavelength for dasatinib at 324\u2009nm. SMEDDS formulations comprised Capryol 90, Transcutol HP, and Tween 40. The method was validated according to ICH guidelines, demonstrating excellent linearity (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.9993), accuracy (recovery between 98% and 101%), and precision (relative standard deviation of 0.73%). It also showed stability and reliability with limits of detection and quantification of 0.17 and 0.50\u2009\u00b5g\/mL, respectively. This RP\u2010HPLC method meets all validation criteria and provides a robust, cost\u2010effective tool for analyzing dasatinib in SMEDDS formulations.\n                  <\/jats:p>","DOI":"10.1155\/ianc\/4376722","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:27:19Z","timestamp":1770010039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development and Validation of a Robust RP\u2010HPLC Method for Quantifying Dasatinib in Self\u2010Microemulsifying Drug Delivery Systems"],"prefix":"10.1155","volume":"2026","author":[{"given":"Nitin V.","family":"Kokare","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit R.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana Salman Saad","family":"Al-Rashidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuntal","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1533-9667","authenticated-orcid":false,"given":"Syed Mohammed Basheeruddin","family":"Asdaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa F.","family":"Alsanie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulhakeem S.","family":"Alamri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Alhomrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal F.","family":"Alshammary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Arif","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Imam","family":"Rabbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanumantharayappa","family":"Bylappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Alshehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"29","article-title":"Dasatinib: Recent Results","volume":"212","author":"Lindauer M.","year":"2018","journal-title":"Cancer Research"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9107-21"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008216"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-020-00872-4"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/2211738511666230112123235"},{"key":"e_1_2_10_6_2","article-title":"Oleic Acid-Based Self Micro-Emulsifying Delivery System for Enhancing Antifungal Activities of Clotrimazole","volume":"14","author":"Yang T. 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