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A dual\u2010function RP\u2010HPLC method was used to analyze the assay and dissolution testing of MTH and DCL K simultaneously. As part of the suggested method, green and white analytical chemistry standards were incorporated to ensure sustainability and compatibility. We performed a chromatographic separation on a C8 column (15\u2009cm\u2009\u00d7\u20094.6\u2009mm, 5\u2009\u03bcm) with a mobile phase of phosphate buffer and ethanol (30:70\n                    <jats:italic>v<\/jats:italic>\n                    \/\n                    <jats:italic>v<\/jats:italic>\n                    ), adjusted to pH 2.5\u2009\u00b1\u20090.1, yielding sharp and well\u2010resolved peaks with retention times of 2.183\u2009min for MTH and 6.652\u2009min for DCL. A 275\u2010nm dual UV detector was used to detect the separation at a flow rate of 1.0\u2009mL\/min. Sensitivity parameters demonstrated low detection capabilities, with limits of detection (LOD) of 0.069\u2009\u03bcg\/mL for MTH and 0.012\u2009\u03bcg\/mL for DCL, and limits of quantification (LOQ) of 0.210\u2009\u03bcg\/mL and 0.035\u2009\u03bcg\/mL. Over an extended sample period of 30\u2009min with 100\u2009revolutions per minute (rpm), USP Apparatus II (Paddle) was used to measure dissolution at a temperature of 37.0\u2009\u00b1\u20090.5\u00b0C in phosphate buffer (pH 6.8). With both active pharmaceutical ingredients, 75% of the drug was released within 30\u2009min.\u2009A combination of suitability (RSD 2%) and precision (raw data 2%) makes the method an excellent choice for routine quality control. In keeping with the changing environment and regulatory requirements, pharmaceutical analysis can become more efficient and sustainable. Accelerated stability studies were conducted on the finished dosage form under ICH\u2010recommended conditions for 6\u2009months. Sustainability was assessed using the Analytical Eco\u2010Scale, Environmental and Practical Performance Index (EPPI), and Click Analytical Chemistry Index (CACI). The method achieved an Eco\u2010Scale score of 91, classifying it as an excellent green method, an EPPI score of 97.9, and a CACI score of 80, confirming its efficiency and practicality for routine quality control.\n                  <\/jats:p>","DOI":"10.1155\/ianc\/8947770","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:18:28Z","timestamp":1776755908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eco\u2010Conscious RP\u2010HPLC Method for Concurrent Quantification of Assay and Dissolution Testing of Methocarbamol and Diclofenac Potassium in Tablet 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