{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:39:10Z","timestamp":1753886350486,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,3,7]],"date-time":"2006-03-07T00:00:00Z","timestamp":1141689600000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Tramedico BV, The Netherlands"},{"DOI":"10.13039\/100001610","name":"Falk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013017","name":"VU University Medical Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013017","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation of Immunogenetics"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tObjective. The aim of this study was to determine if \n        vaginal application of the immune response modifier\nimiquimod (Aldara cream, 3M Pharmaceuticals, St Paul, Minn) would\nalter the course and\/or outcome of female genital tract infection\nwith a human isolate of Chlamydia trachomatis in a murine\nmodel. Methods. Groups of CF\u20101 mice were treated with\nAldara on three different schedules: (1) ongoing beginning 5 days\nprior to and continuing through day 5 of infection; (2) a single\nprophylactic dose 2 hours prior to infection; and (3) therapeutic\nfrom day 4 to day 14 of infection. Mice were infected\nvaginally with a serovar D strain of C trachomatis, and\nmonitored by culture to determine the level of shedding and\nduration of infection. Results. We observed a significant\nreduction in both duration of infection and the level of shedding\nduring the acute phase in mice treated on an ongoing basis\ncommencing 5 days prior to infection. There was no effect \nwith respect to the other regimens. Conclusion.\nThese results demonstrate that ongoing Aldara treatment has\nefficacy and may enhance local innate immunity which reduces the\nduration of subsequent infection with human isolates of C\ntrachomatis in a murine model of female genital tract infection.<\/jats:p>","DOI":"10.1155\/idog\/2006\/61265","type":"journal-article","created":{"date-parts":[[2006,6,21]],"date-time":"2006-06-21T10:09:35Z","timestamp":1150884575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of an Immune Modulator in Experimental Chlamydia trachomatis Infection of the Female Genital Tract"],"prefix":"10.1155","volume":"2006","author":[{"given":"Joseph M.","family":"Lyons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James I.","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Servaas 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