{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:38:34Z","timestamp":1787647114160,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T00:00:00Z","timestamp":1140566400000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100006942","name":"Medical University of South Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006942","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tObjective. To obtain pilot data on the endometrial histology of\nDepomedroxyprogesterone acetate (Depo\u2010Provera, DMPA) users\nexperiencing breakthrough bleeding (BTB) versus users with\namenorrhea. To compare the endometrial histology of patients who\nused DMPA continuously for 3\u201312 months versus those who used it for\n13 months or more. Methods. Cross\u2010sectional study. Endometrial\nbiopsy was obtained from all consenting patients who used DMPA for at\nleast 3 months. Patients were divided into those with BTB in the last 3 months\nversus those with amenorrhea for at least 3 months. Histology\nresults and duration of therapy were compared. Results. The\nproportion of women with chronic endometritis, uterine polyps,\natrophic, proliferative, or progesterone\u2010dominant endometrium did\nnot differ between those DMPA users with BTB versus those with\namenorrhea. Duration of therapy did not correlate with symptoms of\nBTB or endometrial histology. Chronic endometritis was the most\ncommon histologic finding (10\/40, 25%) and occurred more often\nin women experiencing BTB (35% versus 15%) (RR 1.62 CI\n0.91\u20132.87). Moreover, 45% of women with BTB had received\nDMPA for more than 12 months. Conclusions. BTB was more common\nthan previously reported in women using DMPA for more than 12\nmonths. Chronic endometritis, which may indicate an underlying\ninfectious or intracavitary anatomic etiology, has not been\npreviously reported as a frequent finding in DMPA users, and may\nbe related to ethnic or other sociodemographic characteristics of\nour patient population. Further study to elucidate the etiology of\nchronic endometritis in these patients is warranted.<\/jats:p>","DOI":"10.1155\/idog\/2006\/69402","type":"journal-article","created":{"date-parts":[[2006,6,21]],"date-time":"2006-06-21T10:09:35Z","timestamp":1150884575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Endometrial Histology of Depomedroxyprogesterone Acetate Users: A Pilot Study"],"prefix":"10.1155","volume":"2006","author":[{"given":"Andrea Ries","family":"Thurman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Soper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,22]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"962","article-title":"Long-acting methods of contraception","author":"Speroff 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