{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:50:35Z","timestamp":1781938235038,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":169,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Breast Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Locally advanced breast cancer (LABC) remains a major therapeutic challenge, with neoadjuvant chemotherapy (NAC) serving as a cornerstone of management. However, direct evidence comparing the efficacy of sequential (AC\u2010T) and concurrent (TAC) anthracycline\u2013taxane regimens in real\u2010world Middle Eastern populations remains scarce. This study is aimed at comparing the clinical outcomes of AC\u2010T and TAC in Iranian women with LABC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort study was conducted among 118 patients with Stage III breast cancer treated at Tehran, Iran. Patients received either AC\u2010T (doxorubicin\/cyclophosphamide followed by paclitaxel;\n                      <jats:italic>n<\/jats:italic>\n                      = 70) or TAC (docetaxel\/doxorubicin\/cyclophosphamide;\n                      <jats:italic>n<\/jats:italic>\n                      = 48). Outcomes included pathological complete response (pCR), overall survival (OS), disease\u2010free survival (DFS), distant recurrence\u2010free survival (DRFS), and locoregional recurrence\u2010free survival (LRFS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline demographic and clinical characteristics were comparable between groups. No significant difference in pCR rates was observed between the groups. The AC\u2010T regimen showed higher, though nonsignificant, OS at 3, 5, and 10 years (90%, 82%, and 71%, respectively) compared with TAC (83%, 74%, and 57%). Conversely, TAC demonstrated significantly superior 10\u2010year DRFS (62% vs. 45%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.019). DFS and LRFS were similar between regimens. Multivariable Cox regression analysis identified ER positivity as the only independent predictor of improved OS (HR = 0.42, 95% CI: 0.29\u20130.82,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012) and DFS (HR = 0.36,  95% CI: 0.18\u20130.73,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005), whereas the chemotherapy regimen was not independently associated with survival after adjustment for confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both AC\u2010T and TAC provided effective neoadjuvant control in LABC, with comparable survival outcomes. These findings support individualized regimen selection based on patient profile and tumor biology. Prospective studies are needed to refine region\u2010specific treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijbc\/6630563","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:06:48Z","timestamp":1781935608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of AC\u2010T Versus TAC Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer: A Retrospective Analysis"],"prefix":"10.1155","volume":"2026","author":[{"given":"Mehrzad","family":"Mirzania","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Anari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Amir Hossein","family":"Emami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Roudini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4388-0214","authenticated-orcid":false,"given":"Mehdi","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kianmehr","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-9379","authenticated-orcid":false,"given":"Masoud","family":"Mortezazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-7842","authenticated-orcid":false,"given":"Ahmad","family":"Khajeh-Mehrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33587"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-12151-6"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2021.12.011"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62422-8"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3492"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu007"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0031"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.1275"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03399"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2016.06.02"},{"key":"e_1_2_11_12_2","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2022.40.16_suppl.e18690","article-title":"Real-World Outcomes of Neoadjuvant Chemotherapy for Breast Cancer: Reflections From a Community Cancer Center","volume":"40","author":"Bhardwaj P. V.","year":"2022","journal-title":"Journal of Clinical Oncology"}],"container-title":["International Journal of Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijbc\/6630563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ijbc\/6630563","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijbc\/6630563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:06:50Z","timestamp":1781935610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ijbc\/6630563"}},"subtitle":[],"editor":[{"given":"Sreeja","family":"Dattachoudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ijbc\/6630563"],"URL":"https:\/\/doi.org\/10.1155\/ijbc\/6630563","archive":["Portico"],"relation":{},"ISSN":["2090-3170","2090-3189"],"issn-type":[{"value":"2090-3170","type":"print"},{"value":"2090-3189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6630563"}}