{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:46:12Z","timestamp":1782798372741,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":179,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Breast Cancer"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High breast density is commonly observed in younger breast cancer patients (&lt;45 years), and Asian women generally have dense breasts even beyond the age of 45 years. Its relationship with breast cancer subtypes and its profile remains unclear. This study is aimed at exploring the association between mammographic density and breast cancer molecular subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study evaluating mammographic density based on the 2013 BI\u2010RADS classification among breast cancer patients at Dharmais Cancer Hospital between 2021 and 2023 was conducted. Clinicopathological variables\u2014including histological subtype, tumor grade, ER, PR, HER2 status, Ki\u201067 index, and molecular subtypes by immunohistochemistry\u2014were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      High breast density (BI\u2010RADS C and D) was observed in 69% of patients, with Category C being the most common (57.1%). Invasive ductal carcinoma of no special type was the most prevalent and 47.2% of tumors were high grade. Most tumors were ER\u2010negative (67.1%), PR\u2010negative (59.6%), and HER2 0 (54.0%), with high Ki\u201067 index in 70.2% of cases. Age was associated with breast Density C and D and TNBC molecular subtype (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). HER2, Ki\u201067, and molecular subtype were negatively correlated with ER (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.217,\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.283, and\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.851, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05) and with PR (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.169,\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.287, and\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.840, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Conversely, HER2 and Ki\u201067 expressions were positively correlated with more aggressive molecular subtypes (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.307 and\n                      <jats:italic>r<\/jats:italic>\n                      = 0.354, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Younger breast cancer patients were associated with higher breast density and more aggressive tumor subtypes, which correlated with HER2 and Ki\u201067 expressions in breast cancer. These underscore the relevance of age\u2010related biological factors in shaping breast cancer characteristics. However, among Indonesian women over 45 years old, the proportion of high breast density remains remarkably high (65.6%), suggesting that factors beyond age\u2014such as genetic, hormonal, or lifestyle influences\u2014may contribute to the persistence of dense breast tissue in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijbc\/8401844","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:33:03Z","timestamp":1782797583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Mammographic Density in Younger Women and Its Implications for Breast Cancer 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Ifandriani","family":"Putri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5932-872X","authenticated-orcid":false,"given":"Vincent","family":"Laiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0750-5742","authenticated-orcid":false,"given":"Intan","family":"Mupangat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozan Muhammad","family":"Irfan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4221-9583","authenticated-orcid":false,"given":"Zannuba Arifah","family":"Noor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9854-3959","authenticated-orcid":false,"given":"Putri 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