{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:53:49Z","timestamp":1772985229960,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":361,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Breast Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We set out to assess whether the extensive intraductal component (EIC) status in invasive breast cancers serves as an independent predictor of residual disease (RD) in re\u2010excisions performed at our institution. This laboratory\u2010based study provides insights into the thresholds for additional surgical intervention in cases with close ductal carcinoma in situ (DCIS) margins following initial breast\u2010conserving surgery (BCS). We also examined the unique characteristics specific to EIC\u2010positive cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>BCS cases with invasive breast cancer and DCIS with close margins that had re\u2010excisions following initial surgery (Dec 2019\u2013Dec 2024) were selected and classified into EIC positive or EIC negative. Data collected on the initial excision included the EIC status and other clinicopathological information such as margin status, DCIS extent, cancer type and focality, TNM stage, biomarker status, and OncotypeDX Recurrence Score (RS). The RD status was collected on re\u2010excision specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010one cases were included (57 EIC positive and 34 EIC negative), with most being invasive ductal carcinoma. The rate of RD on re\u2010excision was 70.2% and 32.4% in EIC\u2010positive and EIC\u2010negative cases, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). EIC\u2010positive cases showed a higher tendency to involve multiple margins, had a lower T stage and greater DCIS extent, and they were more commonly associated with multifocal cancer. Finally, when assessing predictors of RD, EIC status emerged as the most significant factor among other variables (adjusted odds ratio\u2009=\u20093.39). Secondary findings included a relatively increased proportion of EIC\u2010positive cases (19%) exhibiting mucinous morphology (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0063) and HER2\u2010positive tumor status (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.035).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings show that EIC status is the most significant predictor of RD following BCSs with close DCIS margins. This emphasizes the importance of identifying EIC\u2010positive cases in pathology reports and prioritizing them for additional re\u2010excision when DCIS margins are close.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijbc\/8785445","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T06:12:38Z","timestamp":1766988758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extensive Intraductal Component (EIC) as the Most Predictive Factor for Residual Disease Post\u2013Breast\u2010Conserving Surgery With Close DCIS Margins: A Single Institutional Experience"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-6895","authenticated-orcid":false,"given":"Ibrahim","family":"Elsharawi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-759X","authenticated-orcid":false,"given":"Gillian","family":"Bethune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_11_1_2","volume-title":"Protocol for the Examination of Resection Specimens from Patients with Invasive Carcinoma of the Breast","author":"Krishnamurti U. 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