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The cross\u2010linked ligand biopolymer was prepared, and its reactions with iron(III) chloride and chromium(III) chloride were performed. The obtained complexes were characterized using techniques, including elemental analysis, FT\u2010IR, and UV\u2013Vis. spectroscopy, XRD, and SEM, which confirmed structural integrity, electronic transitions, and unique morphologies of them. The crystallite size of all nanostructured coordination polymers was in the range of 35\u201340\u2009nm. Thermal analysis (thermogravimetry, derivative thermogravimetry, and differential thermal studies) has been used to study the thermal decomposition stages. All the synthesized coordination polymers were nonelectrolytes with magnetic moments ranging from 3.91 to 5.92 BM. The antimicrobial and antioxidant capabilities of the nanosized metal coordination polymers confirmed their potential to mitigate oxidative stress and related disorders and revealed excellent biocompatibility of the polymeric complexes. Furthermore, preliminary anticancer studies indicated that these Fe(III) and Cr(III) nanosized coordination polymers exhibit significant cytotoxic effects against breast MCF\u20107 cancer cell lines and no toxicity against normal cell lines, suggesting their potential as drug delivery systems or therapeutic agents.<\/jats:p>","DOI":"10.1155\/ijbm\/3245959","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:16:31Z","timestamp":1783145791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Characterization, and Study of the Bioactivity of Nanosized Fe(III) and Cr(III) Coordination Polymers Based on Cross\u2010Linked Sodium Alginate and Polyacrylic Acid Biopolymers"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-4427","authenticated-orcid":false,"given":"Maged S.","family":"Al-Fakeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1050-3682","authenticated-orcid":false,"given":"Maryam","family":"Aldoghaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munirah S.","family":"Alazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassine","family":"El-Ghoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-6135","authenticated-orcid":false,"given":"Ahmed B. 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