{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:24:09Z","timestamp":1753889049117,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":353,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["14162016"],"award-info":[{"award-number":["14162016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515011547"],"award-info":[{"award-number":["2019A1515011547"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> This study aimed to verify the effect of angiotensin (1\u20137) on improving islet function and further explore the signaling pathway that may be involved in this improvement. It also aimed to explore the effects of angiotensin (1\u20137) on blood glucose levels, islet function, and morphological changes in db\/db mice and its potential signal pathway.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010five db\/db mice were divided randomly into a model control group and different doses of angiotensin (1\u20137) intervention groups (0, 150, 300, and 600\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg\/d), while seven db\/m mice were assigned as the normal control group. The angiotensin (1\u20137) intervention groups received daily intraperitoneal administration for 8\u2009weeks, whereas the normal control group was injected intraperitoneally with an equal volume of normal saline every day for 8\u2009weeks. Changes in weight and food intake of mice were detected. Effect of angiotensin (1\u20137) on lipid metabolism, islet function, the morphology of pancreatic islets, and <jats:italic>\u03b2<\/jats:italic>\u2010cell mass on mice were evaluated. The expression of PDX\u20101 and GCK in pancreatic tissue was verified.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The group receiving angiotensin (1\u20137) at a dosage of 600\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg\/d showed a significant decrease in body weight, triglyceride levels, and fasting blood glucose, along with an improvement in glucose tolerance. In the 300\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg\/d group, angiotensin (1\u20137) tended to increase the total volume of islets. Moreover, the intervention groups exhibited a significant increase in the ratio of <jats:italic>\u03b2<\/jats:italic> cells, small islets (30\u201380\u2009<jats:italic>\u03bc<\/jats:italic>m in diameter), as well as the expression levels of PDX\u20101 and GCK in pancreatic tissue.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Angiotensin (1\u20137) could improve glucose and lipid metabolism and islet function by promoting the expression of PDX\u20101 and GCK genes in the pancreas of db\/db mice.<\/jats:p>","DOI":"10.1155\/ije\/1672096","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T17:10:31Z","timestamp":1734628231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiotensin (1\u20137) Improves Pancreatic Islet Function via Upregulating PDX\u20101 and GCK: A Dose\u2010Dependent Study in 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