{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:40:28Z","timestamp":1787920828440,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":231,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-002"],"award-info":[{"award-number":["2021-I2M-1-002"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Primary hyperparathyroidism (pHPT) caused by parathyroid neoplasm is a common endocrine disorder. Nuclear staining loss of parafibromin, encoded by the\n                    <jats:italic>CDC73<\/jats:italic>\n                    gene, has been shown to be closely related to parathyroid malignancy and poor prognosis. Although previous studies have found that parafibromin staining loss is not always consistent with\n                    <jats:italic>CDC73<\/jats:italic>\n                    mutation, the reasons are still unknown.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Published studies from the PubMed database were searched using the terms \u201cparafibromin,\u201d \u201c\n                    <jats:italic>CDC73<\/jats:italic>\n                    ,\u201d \u201c\n                    <jats:italic>HRPT2<\/jats:italic>\n                    ,\u201d and \u201cparathyroid\u201d to identify eligible studies. Among the included studies,\n                    <jats:italic>CDC73<\/jats:italic>\n                    mutation and parafibromin immunohistochemical (IHC) results for patients with parathyroid neoplasms were reviewed, and possible reasons for the inconsistency between the parafibromin staining loss and\n                    <jats:italic>CDC73<\/jats:italic>\n                    mutation were explored. This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) 2020 analysis protocol.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 299 patients from 32 studies were included in the present review. Inconsistency and consistency between parafibromin staining and\n                    <jats:italic>CDC73<\/jats:italic>\n                    status was observed in 19.40% and 80.60% of patients. Patients in the inconsistency group showed higher level of serum calcium (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.026). Significant difference in the inconsistency rate was found between PC (25.15%) and non\u2010PC group (12.50%) (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), and NGS (8.51%) and non\u2010NGS group (21.43%) (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.006) in multivariate analysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The main reasons for the inconsistency were attributed to the pathological type and sequencing method. More inconsistent results were detected in the PC group and the non\u2010NGS group.\n                  <\/jats:p>","DOI":"10.1155\/ije\/1905585","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T08:49:51Z","timestamp":1755679791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Consistency of\n                    <i>CDC73<\/i>\n                    Mutation and Parafibromin Staining Loss in Parathyroid Neoplasm: A Systematic Review"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0136-4160","authenticated-orcid":false,"given":"Jinheng","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-9947","authenticated-orcid":false,"given":"Ya","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2021.08.003"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)31430-7"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09709-1"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1761030"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20446"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.834362"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1530\/erc-20-0149"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20181778"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14161"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1530\/ec-13-0046"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-012-0100-x"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20911"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.12.012"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc-09-0134"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0000000000001017"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33166"},{"key":"e_1_2_13_17_2","volume-title":"WHO\/IARC Classification of Tumours (4th Edition, Volume 10): WHO Classification of Tumours of Endocrine Organs","author":"Lloyd R. 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