{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:35:53Z","timestamp":1789785353823,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Growth hormone deficiency (GHD) and idiopathic short stature (ISS) are common causes of short stature in children. In China, PEGylated recombinant human GH (PEG\u2010rhGH, Jintrolong) has been approved for the treatment of both conditions. This study aimed to evaluate the efficacy and safety of PEG\u2010rhGH in children diagnosed with GHD or ISS and to compare clinical outcomes between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This real\u2010world study included 91 treatment\u2010na\u00efve children with short stature at Kunming Children\u2019s Hospital between 2020 and 2021. Participants were categorized into the GHD group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939) and the ISS group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952) based on etiological diagnosis. All subjects received weekly subcutaneous PEG\u2010rhGH injections at an initial dose of 0.20\u2009mg\/kg\/wk and were followed for 18\u2009months. Growth\u2010related parameters were assessed throughout the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PEG\u2010rhGH treatment significantly improved height standard deviation score (Ht SDS) in both groups. In the GHD group, Ht SDS increased from \u22123.14 (\u22124.06, \u22122.02) at baseline to \u22121.53 (\u22121.98, \u22121.08) at Month 18 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), with a mean \u0394Ht SDS of 1.69\u2009\u00b1\u20090.98. The ISS group demonstrated an improvement from \u22123.33\u2009\u00b1\u20091.23 at baseline to \u22121.33 (\u22122.03, \u22120.92) at 18\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), with a mean \u0394Ht SDS of 1.77\u2009\u00b1\u20091.06. No significant differences were identified between the groups regarding Ht SDS, \u0394Ht SDS, Insulin\u2010Like Growth Factor 1 SDS (IGF\u20101 SDS), \u0394IGF\u20101 SDS, or height velocity (all\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). Thyroid function markers (T3, T4, FT3, FT4) and fasting plasma glucose levels remained within normal ranges throughout treatment, with no significant intergroup differences (all\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). No serious adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PEG\u2010rhGH effectively promoted height gain in children with GHD and ISS, with similar therapeutic efficacy in both groups. However, children with ISS required a longer duration to achieve catch\u2010up growth to normal height, potentially due to reduced GH sensitivity and a need for higher dosing. PEG\u2010rhGH was well tolerated, with a favorable safety profile in both cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/2058589","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:38:52Z","timestamp":1769153932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of PEGylated Recombinant Human Growth Hormone in Children With Growth Hormone Deficiency and Idiopathic Short Stature: A Real\u2010World Cohort Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1415-9840","authenticated-orcid":false,"given":"Liping","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6476-2001","authenticated-orcid":false,"given":"Canmiao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7816-7457","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7340-567X","authenticated-orcid":false,"given":"Lijun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7970-7005","authenticated-orcid":false,"given":"Meiyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2715-467X","authenticated-orcid":false,"given":"Yanfang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3525-2085","authenticated-orcid":false,"given":"Fang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1598-5404","authenticated-orcid":false,"given":"Qi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1556-1206","authenticated-orcid":false,"given":"Na","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ped4.12233"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00539-5"},{"key":"e_1_2_13_3_2","first-page":"401","article-title":"Prevalence of Growth Hormone Deficiency of Children in Beijing","volume":"105","author":"Bao X. 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