{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:10:33Z","timestamp":1789805433459,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":261,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to analyze the applicability of different shear wave elastography (SWE) methods in the diagnosis, differentiation, and monitoring of subacute thyroiditis (SAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective study included 26 patients diagnosed with SAT and 40 healthy controls. All participants underwent conventional B\u2010mode ultrasonography followed by two\u2010dimensional shear wave elastography (2D\u2010SWE), using a 4\u201315\u2009MHz linear transducer (Aixplorer, Supersonic Imagine, France). Thyroid stiffness was assessed in kilopascals (kPa) and evaluated at diagnosis, 4\u2009weeks, and 8\u2009weeks. Statistical analysis included\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, repeated\u2010measures ANOVA, receiver operating characteristic curve analysis, and Youden Index calculation to determine optimal diagnostic cut\u2010off values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline thyroid stiffness in SAT patients was significantly higher than in controls (127.25\u2009\u00b1\u200954.06\u2009kPa vs. 19.5\u2009\u00b1\u20097.1\u2009kPa;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Stiffness values decreased over time, reaching 117\u2009\u00b1\u200944.67\u2009kPa at 4\u2009weeks and 57.17\u2009\u00b1\u200922.89\u2009kPa at 8\u2009weeks. An exploratory cutoff value of 37.2\u2009kPa showed complete separation between groups within this specific cohort. Beyond baseline group differences, the most relevant finding was the longitudinal change in thyroid stiffness during clinical recovery, supporting the role of SWE as a quantitative imaging biomarker of inflammatory activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>2D\u2010SWE showed promising performance as a quantitative imaging biomarker for evaluating and monitoring SAT in this exploratory cohort. It provides valuable quantitative data on tissue stiffness, complementing conventional ultrasound and aiding clinical decision\u2010making during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/4035441","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:31:17Z","timestamp":1789803077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic and Monitoring Value of 2D Shear Wave Elastography in Subacute Thyroiditis: A Prospective Case\u2013Control Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6032-6246","authenticated-orcid":false,"given":"Ioana","family":"Golu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-1380","authenticated-orcid":false,"given":"Melania","family":"Balas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5042-5539","authenticated-orcid":false,"given":"Mervat","family":"Matei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toma","family":"Andreea-Daniela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4043-5862","authenticated-orcid":false,"given":"Ana","family":"Corlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-8748","authenticated-orcid":false,"given":"Daniel","family":"Luches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-2487","authenticated-orcid":false,"given":"Dana","family":"Amzar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8173-3252","authenticated-orcid":false,"given":"Natalia","family":"Milos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-9223","authenticated-orcid":false,"given":"Ioan","family":"Sporea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-7228","authenticated-orcid":false,"given":"Alina","family":"Popescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-1650","authenticated-orcid":false,"given":"Mihaela","family":"Vlad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/endocrines3030031"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-021-09648-y"},{"key":"e_1_2_14_3_2","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.7863\/ultra.15.09049","article-title":"Sonographic Characteristics and Interval Changes of Subacute Thyroiditis","volume":"35","author":"Yoo J. L.","year":"2016","journal-title":"Journal of Ultrasound in Medicine"},{"key":"e_1_2_14_4_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/0284185113498721","article-title":"Ultrasound Findings of Subacute Thyroiditis: A Single Institution Retrospective Review","volume":"55","author":"Cappelli C.","year":"2014","journal-title":"Acta Radiologica"},{"key":"e_1_2_14_5_2","doi-asserted-by":"crossref","DOI":"10.1186\/s12902-019-0415-y","article-title":"Thyroid Primary and Metastatic Malignant Tumours of Poor Prognosis May Mimic Subacute Thyroiditis-Time to Change the Diagnostic Criteria: Case Reports and a Review of the Literature","volume":"19","author":"Stasiak M.","year":"2019","journal-title":"BMC Endocrine Disorders"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2013.01.022"},{"key":"e_1_2_14_7_2","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1210\/jc.2007-0641","article-title":"Elastography: New Developments in Ultrasound for Predicting Malignancy in Thyroid Nodules","volume":"92","author":"Rago T.","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_14_8_2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1109\/TUFFC.2004.1295425","article-title":"Supersonic Shear Imaging: A New Technique for Soft Tissue Elasticity Mapping, 2004 Elasticity Mapping","volume":"51","author":"Bercoff J.","year":"2004","journal-title":"IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2016.06.022"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1335205"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.05.008"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0766"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2018.03.019"},{"key":"e_1_2_14_14_2","first-page":"35","article-title":"Elastosonography of Thyroid Lesions","volume":"89","author":"Tranquart F.","year":"2008","journal-title":"Journal de Radiologie"},{"key":"e_1_2_14_15_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-2008-1027442","article-title":"Differential Diagnosis of Benign and Malignant Thyroid Nodules at Elastosonography","volume":"30","author":"Rubaltelli L.","year":"2009","journal-title":"Ultraschall in der Medizin"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04170.x"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2495-1"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1595"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje-11-0736"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2006.7.4.229"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1246048"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-015-0754-2"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1325330"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.11.7009"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000008282"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59081488"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2022.04.128"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ije\/4035441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ije\/4035441","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ije\/4035441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:31:19Z","timestamp":1789803079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ije\/4035441"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ije\/4035441"],"URL":"https:\/\/doi.org\/10.1155\/ije\/4035441","archive":["Portico"],"relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4035441"}}