{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:55:23Z","timestamp":1781337323451,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":162,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460299"],"award-info":[{"award-number":["82460299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects fertility through oligo weathering, hyperandrogenism, and polycystic morphology of the ovary. Currently, D\u2010chiral inositol (DCI) treatment of PCOS has yielded satisfactory results by targeting steroid biosynthesis, but a deeper understanding of the potential mechanisms and efficacy of this treatment regimen is needed. The aim of this study was to determine the effects of DCI use on endocrine and metabolic abnormalities in women with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A PCOS rat model was developed via letrozole induction. After successful modeling, letrozole was administered orally to the rats for 4\u2009weeks (PCOS\u2009+\u2009DCI). Enzyme\u2010linked immunosorbent assay was used to examine changes in serum hormone levels in PCOS rats and PCOS\u2009+\u2009DCI rats, and transcriptomics was used to detect changes in the expression of related target genes and signaling pathways. Furthermore, amino acid\u2013targeted metabolomics was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      DCI intervention effectively improved the symptoms of PCOS in the rats, including polycystic ovary\u2010like changes and serum sex hormone and insulin levels. Further transcriptomic validation showed significant changes in the expression of genes such as\n                      <jats:italic>Lamc2<\/jats:italic>\n                      ,\n                      <jats:italic>Inhba<\/jats:italic>\n                      , and\n                      <jats:italic>Bdkrb2<\/jats:italic>\n                      in DCI\u2010treated rats. Metabolomic validation targeting amino end groups revealed that DCI effectively improved amino acid metabolism in PCOS rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirmed that DCI can not only alleviate the reproductive and metabolic abnormalities of PCOS phenotypically but also regulate gene expression and metabolic networks at the molecular level. Its therapeutic effect has the characteristics of being multitarget and systematic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/5563183","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:57:41Z","timestamp":1781333861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of D\u2010Chiral Inositol on Amino Acid Metabolism in a PCOS Rat 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