{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:02:18Z","timestamp":1789628538275,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":258,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["25758"],"award-info":[{"award-number":["25758"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Endoplasmic reticulum stress (ERS) plays a pivotal role in the development of diabetes\u2010induced liver damage. Under elevated ERS, the unfolded protein response (UPR) balances cellular survival and death. There may be a preventive effect of herbal extracts against problems associated with diabetes. In this study, the effects of a hydroalcoholic extract from\n                      <jats:italic>Dorema aucheri<\/jats:italic>\n                      on liver damage, ERS, and UPR in diabetic rats were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      There were five groups of rats, each including six rats. A 60\u2009mg\/kg intraperitoneal injection of streptozotocin (STZ) was used to cause diabetes. Every day, 1\u2009mL of normal saline was given to the control groups, who were normal and diabetic. For 28\u2009days, three diabetic groups were given oral gavage doses of 250\/500\u2009mg\/kg of\n                      <jats:italic>D. aucheri<\/jats:italic>\n                      extract and 500\u2009mg\/kg of metformin daily. Serum and liver samples were used to assess blood glucose, liver enzymes, oxidative stress, inflammatory markers, and antioxidant levels after treatment. Furthermore, liver tissue pathology, stereology, and gene expression were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the diabetic groups, the treated groups exhibited a significant decrease in oxidative stress, inflammatory markers, liver enzymes, blood glucose, and increased antioxidant capacity. They significantly reduced mRNA levels of proapoptotic markers (\n                      <jats:italic>CHOP<\/jats:italic>\n                      ,\n                      <jats:italic>caspase-9<\/jats:italic>\n                      , and\n                      <jats:italic>NF-\u03baB<\/jats:italic>\n                      ) and increased\n                      <jats:italic>GRP78<\/jats:italic>\n                      ,\n                      <jats:italic>XBP1s<\/jats:italic>\n                      , and\n                      <jats:italic>BCL2<\/jats:italic>\n                      expression, suggesting attenuation of apoptosis and modulation of UPR\u2010related gene expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>D. aucheri<\/jats:italic>\n                      extract may modulate UPR\u2010 and apoptosis\u2010related pathways, alleviate ERS, and potentially reduce diabetes\u2010associated complications in STZ\u2010induced diabetic rats. However, further mechanistic and translational studies are required to confirm these findings and evaluate their clinical relevance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/5570446","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:07:14Z","timestamp":1789625234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Dorema Aucheri<\/i>\n                    Extract Modulates Unfolded Protein Response Pathways in Streptozotocin\u2010Induced Diabetic Rats: A Protective Role Against Hepatic Damage"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5134-4200","authenticated-orcid":false,"given":"Alireza","family":"Raeisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-7732","authenticated-orcid":false,"given":"Farhad","family":"Koohpeyma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9022-8939","authenticated-orcid":false,"given":"Roozbeh","family":"Kiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-2660","authenticated-orcid":false,"given":"Somayeh","family":"Igder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9248-9648","authenticated-orcid":false,"given":"Amir","family":"Maleksabet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6850-4983","authenticated-orcid":false,"given":"Nima","family":"Rahimikashkooli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1848-9850","authenticated-orcid":false,"given":"Narges","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-0159","authenticated-orcid":false,"given":"Mesbah","family":"Shams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-9221","authenticated-orcid":false,"given":"Sanaz","family":"Dastghaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113863"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13030378"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00977"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells7060063"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.06.010"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.4.405"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2456579"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2016.16.02.002"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(00)80082-7"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.10058"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.1.1"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14023265"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00205-8"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27052303"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114264"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-072909-095555"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2024.0013"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.112Digital"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3270"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32562"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.8.4273"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00169.201"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.289298.116"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6020058"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.08.002"},{"key":"e_1_2_14_26_2","first-page":"241","volume-title":"Designer 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