{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T18:07:36Z","timestamp":1778954856985,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":135,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Aim<\/jats:title>\n                    <jats:p>Osteoporosis can be seen in some hematologic diseases, such as BCR::ABL1\u2010negative myeloproliferative neoplasms. The incidence and prevalence of osteoporosis and osteopenia in BCR::ABL1\u2010negative MPN are not very well known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Patients diagnosed with one of the classical BCR::ABL1\u2010negative myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera, and myelofibrosis, were included in the study. Due to the retrospective design, a matched control group was not available, and comparisons with the general population were made for contextual interpretation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010four patients were included. Fifty\u2010eight (61.7%) patients had osteopenia, and 16 (17%) patients had osteoporosis according to femoral dual energy X\u2010ray absorptiometry (DXA) measurements. Fifty\u2010three (58.9%) patients had osteopenia, and 27 (30%) patients had osteoporosis according to lumbar DXA measurements. When both femur and lumbar DXA measurements were evaluated together, 67 (71.3%) patients had osteopenia and 31 (33%) patients had osteoporosis. In patients over 50\u2009years of age, these frequencies were found to be 71.4% for osteopenia and 37.7% for osteoporosis. Osteopenia was significantly associated with female sex, cytoreduction, and longer disease duration (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In the multivariate analysis, female sex was found to be an independent risk factor for osteopenia (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009, OR: 3.70, 95% CI: 1.394\u20139.833). Osteoporosis was significantly associated with disease subtype, female sex, age, and no antiaggregant use (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In the multivariate analysis, older age (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.044, OR: 1.04, 95% CI: 1.001\u20131.083) was found to be an independent risk factor for osteoporosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with BCR::ABL1\u2010negative classical myeloproliferative neoplasms have a higher risk of osteopenia\/osteoporosis compared to the general population. DXA measurements should be performed, especially in female patients and in patients of advanced age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/6041016","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:36:33Z","timestamp":1778952993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Associations of Osteoporosis in BCR::ABL1 Negative Myeloproliferative Neoplasms"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-5275","authenticated-orcid":false,"given":"M\u00fcr\u00fcvvet Seda","family":"Aydin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-2043","authenticated-orcid":false,"given":"Simten","family":"Dagdas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-8573","authenticated-orcid":false,"given":"Mehmet Sezgin","family":"Pepeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-9724","authenticated-orcid":false,"given":"G\u00fclten","family":"Korkmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0543-6266","authenticated-orcid":false,"given":"Aysel","family":"Alper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3893-6618","authenticated-orcid":false,"given":"Elif","family":"A\u00e7\u0131kg\u00f6z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2571-584X","authenticated-orcid":false,"given":"Tugce Nur","family":"Bektas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-2025","authenticated-orcid":false,"given":"Merve","family":"Pamuk\u00e7uo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3173-7614","authenticated-orcid":false,"given":"Funda","family":"Ceran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-5978","authenticated-orcid":false,"given":"Gulsum","family":"Ozet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-017-0324-5"},{"key":"e_1_2_8_2_2","volume-title":"Osteoporosis and Metabolic Bone Diseases Diagnosis and Treatment Guide","author":"Association T. 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