{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:55:48Z","timestamp":1792007748316,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>In 2023, the medical terminology for Nonalcoholic Fatty Liver Disease (NAFLD) and NA SteatoHepatitis (NASH) was updated to Metabolic Dysfunction\u2010Associated SteatoticLiver Disease (MASLD) and MA SteatoHepatitis (MASH). This review highlights the critical epidemiological, pathophysiological, and therapeutic aspects of MASH, focusing on the novel treatment option, resmetirom. Resmetirom, a thyroid hormone receptor\u2010beta (THR\u2010\u03b2) agonist, specifically targets liver function to simulate localized hyperthyroidism, effectively reducing lipid accumulation and liver fibrosis without the systemic effects commonly associated with thyroid hormone therapy. Clinical trials, particularly the pivotal MAESTRO\u2010NASH trial, have demonstrated significant improvements in liver health metrics, achieving primary endpoints by resolving MASH without worsening fibrosis and showing a favorable safety profile. This paper reviews the mechanism of action, efficacy, and safety of resmetirom, providing insight into its potential to change the therapeutic landscape for patients suffering from MASH.<\/jats:p>","DOI":"10.1155\/ije\/6430023","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T09:24:10Z","timestamp":1741685050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Resmetirom: The First Disease\u2010Specific Treatment for MASH"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2231-5906","authenticated-orcid":false,"given":"Ali Mohamed","family":"Mousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5458-7780","authenticated-orcid":false,"given":"Mervat","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5760-5358","authenticated-orcid":false,"given":"Ghaida Mubarak","family":"AlShuraiaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000000670"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17846"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.7570\/jomes23052"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330595"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02108-x"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15631"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04431-w"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02092-2"},{"key":"e_1_2_10_10_2","first-page":"76","article-title":"Updates to Clinical Guidelines for Managing MASLD","volume":"89","author":"Alarc\u00f3n P. P.","year":"2024","journal-title":"Diabetes"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70394"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.155835"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000003355"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(15)00803-x"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2028395"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(22)00070-5"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03018-2"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2036205"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31843"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100563"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.2112"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.08.005"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.07.030"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2023.101174"},{"key":"e_1_2_10_25_2","first-page":"39","article-title":"Therapeutic Options in Non-alcoholic Steatohepatitis (NASH). Are All Agents Alike? Results of a Preliminary Study","volume":"16","author":"Georgescu E. F.","year":"2007","journal-title":"Journal of gastrointestinal and liver diseases: JGLD"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2022.08.001"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000000551"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054861"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.10"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.871100"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1530\/ec-20-0490"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061232"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.572128"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.endmts.2023.100144"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0007"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.17925\/ee.2023.19.1.60"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2309000"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17734"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02603-1"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.70025"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc2402905"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.04.021"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/poh2.100"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-s004"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-024-00051-1"},{"key":"e_1_2_10_46_2","unstructured":"Fda FDA Approves First Treatment for Patients with Liver Scarring Due to Fatty Liver Disease U.S. Food and Drug Administration 2024 https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-treatment-patients-liver-scarring-due-fatty-liver-disease."},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.04.031"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.7326\/annals-24-00206-jc"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.69919"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02958-z"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1109615"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ije\/6430023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ije\/6430023","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ije\/6430023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:30:15Z","timestamp":1772994615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ije\/6430023"}},"subtitle":[],"editor":[{"given":"Aman","family":"Rajpal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/ije\/6430023"],"URL":"https:\/\/doi.org\/10.1155\/ije\/6430023","archive":["Portico"],"relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6430023"}}