{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:53:04Z","timestamp":1787068384512,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":204,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    Lithium (Li), which is extensively used in the treatment of mood disorders such as bipolar disorder, has been associated with hyperparathyroidism. However, the relationship between the serum Li concentration and hyperparathyroidism remains unclear. This study aimed (1) to investigate the incidence of hyperparathyroidism and hypercalcemia in consecutive patients treated with Li, (2) to assess the correlation between serum Li concentration and hyperparathyroidism\/hypercalcemia, and (3) to establish cutoff values for predicting hyperparathyroidism and hypercalcemia based on serum Li concentration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This retrospective cross\u2010sectional study was conducted at the Department of Psychiatry and Department of Medicine at Tokyo Women\u2019s Medical University. Ninety\u2010seven consecutive individuals without renal impairment and with an estimated glomerular filtration rate (eGFR) equal to or greater than 45\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    were included.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Hyperparathyroidism and hypercalcemia were observed in 35.1% and 9.3% of the patients on Li, respectively. The serum Li concentration showed a significant positive correlation with hyperparathyroidism and hypercalcemia, independent of other factors. The cutoff values for predicting hyperparathyroidism and hypercalcemia were 0.52 and 0.62\u2009mEq\/L, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This study confirmed that the high incidence of hyperparathyroidism and hypercalcemia in patients treated with Li. Clinicians should be aware that Li treatment may induce hyperparathyroidism, and a serum Li concentration exceeding 0.52\u2009mEq\/L may pose an increased risk. Monitoring serum calcium and Li concentrations is recommended in patients undergoing Li treatment.\n                  <\/jats:p>","DOI":"10.1155\/ije\/6497151","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T04:19:18Z","timestamp":1753417158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of Serum Lithium Concentrations in Predicting Hyperparathyroidism and Hypercalcemia"],"prefix":"10.1155","volume":"2025","author":[{"given":"Noriyoshi","family":"Takano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2292-2319","authenticated-orcid":false,"given":"Satoshi","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Muraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Inada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuji","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-9767","authenticated-orcid":false,"given":"Atsuhiro","family":"Ichihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"},{"key":"e_1_2_9_2_2","first-page":"1","article-title":"Practice Guideline for the Treatment of Patients With Bipolar Disorder (Revision)","volume":"159","author":"American Psychiatric Association","year":"2002","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-016-0068-y"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6614-6-3"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1995.tb09741.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1996.28864000.x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105057515"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.138.1.106"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/25.10.1806"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(94)90017-5"},{"key":"e_1_2_9_11_2","first-page":"130","article-title":"Lithium and Endocrine Dysfunction","volume":"82","author":"Lerena V. S.","year":"2022","journal-title":"Medicina"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-4217-5_19"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0278-5846(02)00223-3"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000502399"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/IJPSYM.IJPSYM_305_17"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.9.4218"},{"key":"e_1_2_9_18_2","first-page":"171","article-title":"Moans, Stones, Groans, Bones and Psychiatric Overtones: Lithium-Induced Hyperparathyroidism","volume":"42","author":"Lienert D.","year":"2008","journal-title":"Australian and New Zealand Journal of Psychiatry"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2022.01.001"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ije\/6497151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ije\/6497151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ije\/6497151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:28:58Z","timestamp":1772994538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ije\/6497151"}},"subtitle":[],"editor":[{"given":"Suraiya","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/ije\/6497151"],"URL":"https:\/\/doi.org\/10.1155\/ije\/6497151","archive":["Portico"],"relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6497151"}}