{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:52:31Z","timestamp":1792439551819,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":126,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700207"],"award-info":[{"award-number":["81700207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Real\u2010world data on the effect of polyethylene glycol loxenatide (PEG\u2010Loxe) in patients with Type 2 diabetes mellitus (T2DM) with normal body mass index (BMI) are lacking. Therefore, this study aims to observe the effect of PEG\u2010Loxe on the weight of patients with T2DM with different BMIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, retrospective real\u2010world study included patients with T2DM, aged \u2265\u200918\u2009years, and receiving PEG\u2010Loxe\/sodium\u2010glucose cotransporter 2 inhibitor (SGLT2i). The primary endpoint was change in body weight after 24\u2009weeks of treatment. Secondary endpoints included proportion of patients with body weight reduction &lt;\u20095.0% and &lt;\u200910%, changes in BMI, and glycosylated hemoglobin (HbA1c).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 487 patients treated with SGLT2i or PEG\u2010Loxe were identified; after propensity score matching, 68 patients were included in each group. After 24\u2009weeks, the mean change in body weight and BMI was \u22121.2 (\u22122.3, \u22120.1) and \u22120.4 (\u22120.8, \u22120.1) in the PEG\u2010Loxe group and \u22122.4 (\u22123.5, \u22121.3) and \u20100.7 (\u22121.1, \u22120.4) in the SGLT2i group. A \u2265\u20095% and \u2265\u200910% weight loss was noted by 32.4% and 8.8% of patients in the PEG\u2010Loxe group, with a mean change in HbA1c (%) of \u22121.48 (\u22121.98, \u22120.99). Weight loss (\u2265\u20095%) in obese patients (BMI &gt;\u200928\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) was greater (PEG\u2010Loxe: 53.3%, SGLT2i: 57.1%) compared to patients with 24\u2009\u2264\u2009BMI\u2009&lt;\u200928\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (PEG\u2010Loxe: 25.7%, SGLT2i: 41.4%) and BMI\u2009&lt;\u200924\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (PEG\u2010Loxe: 27.8%, SGLT2i: 28%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PEG\u2010Loxe resulted in weight loss and glycemic control in patients with T2DM. The weight loss was negatively correlated with baseline BMI without excessive weight loss in normal BMI, supporting PEG\u2010Loxe\u2019s use in this group.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Chinese Registry of Clinical Trials: ChiCTR2400087532\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/7060233","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:27:38Z","timestamp":1778142458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Polyethylene Glycol Loxenatide Treatment on Body Weight in Patients With Type 2 Diabetes With Different Body Mass Index: A Retrospective Real\u2010World Study"],"prefix":"10.1155","volume":"2026","author":[{"given":"Peng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-3919","authenticated-orcid":false,"given":"Chen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuanyong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yale","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-6833","authenticated-orcid":false,"given":"Benping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_12_1_2","volume-title":"StatPearls","author":"Yashi K.","year":"2024"},{"key":"e_1_2_12_2_2","unstructured":"IDF Diabetes Atlas 2021 | IDF Diabetes Atlas 2024 https:\/\/diabetesatlas.org\/atlas\/tenth-edition\/."},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2024.101130"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn311282-20210304-00142"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1106868"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.342"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-s231"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00203-5"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-069080"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108269"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2020_494"},{"key":"e_1_2_12_14_2","first-page":"83","article-title":"Cooperative Meta-Analysis Group of the Working Group on Obesity in China. 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