{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:01:55Z","timestamp":1784710915101,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":202,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary aldosteronism (PA) is a leading cause of secondary hypertension associated with increased cardiovascular and cerebrovascular risk. Superselective adrenal artery embolization (SAAE) has emerged as a minimally invasive alternative to adrenalectomy and mineralocorticoid receptor antagonists (MRAs). This systematic review and meta\u2010analysis evaluates the efficacy and safety of SAAE in PA management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Web of Science, Embase, and Cochrane Library through June 2026 for studies enrolling patients with PA treated by SAAE. Outcomes of interest were changes in blood pressure (BP), biochemical markers (serum potassium, aldosterone, renin activity, and aldosterone\u2010to\u2010renin ratio), clinical and biochemical response rates, daily defined dose change, and adverse events. Data were pooled using a random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nineteen studies comprising 1242 patients undergoing SAAE met inclusion criteria. SAAE achieved substantial BP reductions: office systolic BP \u221219.71\u2009mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), office diastolic BP \u221210.91\u2009mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), home systolic BP \u221218.58\u2009mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and 24\u2010h ambulatory systolic BP \u221214.57\u2009mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Serum potassium increased +0.34\u2009mmol\/L (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), aldosterone declined \u221246.72\u2009ng\/dL (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and ARR decreased \u221232.64 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Complete clinical response occurred in 27% and partial response in 43%; complete biochemical success was achieved in 48% with partial success in 16%. Antihypertensive burden decreased (\u22120.52 daily defined dose;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Adverse events were predominantly minor (postprocedural pain 37.17%, low\u2010grade fever 8.55%); serious complications were uncommon (&lt; 1%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SAAE is an effective and somewhat safe treatment for PA that achieves meaningful BP control, biochemical normalization, and reduced medication burden. It represents a valuable option for patients ineligible for or intolerant of surgery or MRAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/7534774","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:14:46Z","timestamp":1784708086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Drugs and Surgery: Superselective Adrenal Artery Embolization Redefines Primary Aldosteronism Management\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5112-2436","authenticated-orcid":false,"given":"Kimia","family":"Darmiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-0631","authenticated-orcid":false,"given":"Mehrad","family":"Zare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3393-3451","authenticated-orcid":false,"given":"Alisa","family":"Mohebbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Mirza-Aghazadeh-Attari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-900X","authenticated-orcid":false,"given":"Mohammad Ghasemi","family":"Rad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9557-3359","authenticated-orcid":false,"given":"Afshin","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaf284"},{"key":"e_1_2_12_2_2","article-title":"2025 AHA\/ACC\/AANP\/AAPA\/ABC\/ACCP\/ACPM\/AGS\/AMA\/ASPC\/NMA\/PCNA\/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"86","author":"Jones D. 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