{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:50:13Z","timestamp":1780343413679,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","award":["2023MHPY03"],"award-info":[{"award-number":["2023MHPY03"]}],"id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","award":["2024ZSQN31"],"award-info":[{"award-number":["2024ZSQN31"]}],"id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The systemic immune\u2010inflammation index (SII), an emerging inflammatory biomarker, has been associated with various diseases, but its relationship with thyroid function remains unclear. Our study aimed to investigate the potential connections between SII and thyroid function in the U.S. population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional study using the National Health and Nutrition Examination Survey (NHANES) 2007\u20132012 data to evaluate the association between SII and thyroid function, including free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), and thyroid\u2010stimulating hormone (TSH). Furthermore, the correlation was evaluated using multiple linear regression, smooth curve fitting, and threshold effect analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After multivariable linear regression, higher lgSII levels were independently associated with lower FT3 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), TT3 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22123.06,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0149), and TSH (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0204), whereas TT4 levels were positively associated with lgSII after full adjustment (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0016). Smooth curve fitting revealed an L\u2010shaped relationship between lgSII and FT3 and TSH. Threshold effect analysis identified an inflection point at lgSII\u2009=\u20092.29 (log\u2010likelihood ratio,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In U.S. adults, lgSII was negatively associated with FT3 and TSH and positively associated with TT4. These findings highlight a potential link between systemic inflammation and thyroid function, warranting further prospective studies to investigate causal relationships.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/7554085","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T10:56:33Z","timestamp":1767783393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Systemic Immune\u2010Inflammation Index and Thyroid Function: A Cross\u2010Sectional Population\u2010Based 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