{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:20:43Z","timestamp":1787995243970,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":240,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023RC234"],"award-info":[{"award-number":["2023RC234"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between iron metabolism markers and microalbuminuria in patients with Type 2 diabetes mellitus (T2DM) and metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 137 patients with T2DM and MASLD were enrolled and stratified into microalbuminuria\u2010positive and microalbuminuria\u2010negative groups based on the urinary albumin\u2010to\u2010creatinine ratio (UACR). Iron metabolism markers, including serum ferritin, serum iron, total iron\u2010binding capacity (TIBC), transferrin saturation (TS), and hepcidin, were measured. Hepatic iron and fat content were assessed using magnetic resonance imaging (MRI), including R2\n                      <jats:sup>\u2217<\/jats:sup>\n                      mapping (MRI\u2010R2\n                      <jats:sup>\u2217<\/jats:sup>\n                      ) and proton density fat fraction (MRI\u2010PDFF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with microalbuminuria had significantly higher levels of serum ferritin, serum iron, hepcidin, and MRI\u2010R2\n                      <jats:sup>\u2217<\/jats:sup>\n                      compared with those without microalbuminuria (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Correlation analyses showed that hepcidin (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      = 0.208,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.015) and MRI\u2010R2\n                      <jats:sup>\u2217<\/jats:sup>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      = 0.248,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003) were positively associated with UACR. However, after multivariable adjustment for confounding factors, MRI\u2010R2\n                      <jats:sup>\u2217<\/jats:sup>\n                      remained independently associated with microalbuminuria (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Altered iron metabolism is associated with microalbuminuria in patients with T2DM and MASLD. MRI\u2010R2\n                      <jats:sup>\u2217<\/jats:sup>\n                      , a quantitative imaging marker of hepatic iron content, showed an independent association with microalbuminuria after multivariable adjustment and may provide complementary information for early renal injury assessment in this population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/8147661","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:12:07Z","timestamp":1787994727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Iron Metabolism and Microalbuminuria in Patients With Type 2 Diabetes Mellitus and MASLD"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1024-7181","authenticated-orcid":false,"given":"Huanjia","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-6656","authenticated-orcid":false,"given":"Lingling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2282-7478","authenticated-orcid":false,"given":"Jinhua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3329-4121","authenticated-orcid":false,"given":"Dong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3750-1423","authenticated-orcid":false,"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.11.054"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.12.002"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175144"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.01.013"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1047794"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab176"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154874"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.02.007"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.155804"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787002862"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24038"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-3082"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0021-9"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03667-y"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2024.03.015"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24236"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-025-02501-7"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-02038-3"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-022-02028-1"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3mt00347g"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3863"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-016-0505-7"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03486-w"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199912233412607"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00131"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027631"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.05.008"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041534"}],"container-title":["International 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