{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T09:07:20Z","timestamp":1779527240050,"version":"3.53.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":142,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["CMCC202310"],"award-info":[{"award-number":["CMCC202310"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood glucose fluctuations in patients with brittle diabetes have been a problem for clinicians. A recent study found that transplanting the intestinal flora of healthy people to patients with brittle diabetes can improve their blood glucose fluctuations. However, the underlying mechanism remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Streptozotocin\u2010induced diabetic rats were assigned to receive fecal microbiota transplantation (FMT) from healthy donors or to remain untreated, while normal rats received FMT from brittle diabetes donors or remained untreated. Groups included the normal control group (NC group), the diabetic group (DM group), normal rats with FMT from brittle diabetic patients (NC\u2010DMFMT group), and diabetic rats with FMT from normal individuals (DM\u2010NCFMT group). Blood glucose variability, rat liver glucokinase, and glycogen levels, as well as intestinal short\u2010chain fatty acid content, were detected in each group of rats. Gut microbiota composition was analyzed using 16S rDNA sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the standard deviation of blood glucose (SDBG) (1.664\u2009\u00b1\u20090.427\u2009mmol\/L) in the NC group, that of the DM group (6.879\u2009\u00b1\u20091.475\u2009mmol\/L) was higher. However, the DM\u2010NCFMT group reduced SDBG (4.387\u2009\u00b1\u20090.619\u2009mmol\/L) vs. the DM group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Hepatic glycogen (27.57\u2009\u00b1\u20095.254\u2009mg\/L) was lower in the DM group than in the NC group (55.48\u2009\u00b1\u20099.467\u2009mg\/L) but increased in the DM\u2010NCFMT group (37.59\u2009\u00b1\u20091.283\u2009mg\/L) vs. the DM group. The abundance of Bifidobacteria in the DM group was decreased compared to that in the NC group. In contrast,\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      abundance in the DM\u2010NCFMT group increased after standard human flora transplants (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Correlation and stepwise regression analysis indicated that Bifidobacteria reduced SDBG partly by promoting hepatic glycogen synthesis, with an effect share of 23.01%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Normal individual fecal microbiota transplantation improves glucose variability in DM rats, potentially mediated by enhanced hepatic glycogen synthesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/8852077","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T08:27:23Z","timestamp":1779524843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fecal Microbiota Transplantation From Healthy Donors Reduces Glycemic Variability in Streptozotocin\u2010Induced Diabetic Rats via Enhanced Hepatic Glycogen Synthesis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7273-131X","authenticated-orcid":false,"given":"Min","family":"Dou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9312-1162","authenticated-orcid":false,"given":"Jingwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3642-4595","authenticated-orcid":false,"given":"Xinhua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9534-3265","authenticated-orcid":false,"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8203-6562","authenticated-orcid":false,"given":"Li","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03059.x"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.04.010"},{"key":"e_1_2_14_3_2","article-title":"Efficacy and Safety of Washed Microbiota Transplantation in the Treatment of Brittle Diabetes","volume":"12","author":"Yangyang L.","year":"2020","journal-title":"Chinese Journal of Diabetes"},{"key":"e_1_2_14_4_2","volume-title":"Practical Endocrinology","author":"Liu X. 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