{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:09:36Z","timestamp":1773004176203,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":327,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["71046"],"award-info":[{"award-number":["71046"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acromegaly is a rare but severe condition characterized by the excessive secretion of growth hormone (GH), leading to various metabolic alterations. Treatment options include surgery, pharmacotherapy, and radiotherapy (RT). RT can control the disease biochemically, either alone or in conjunction with medical therapy. This study aimed to evaluate the effectiveness of conventional RT in patients with postoperative acromegaly over a 15\u2010year follow\u2010up period, using specific cutoff criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on 55 acromegaly patients who were monitored for an average of 15 (13.3\u201316.7) years and treated with conventional RT (median dose of 52\u2009Gy) following pituitary surgery. Hormonal assessments included baseline and glucose\u2010suppressed GH and IGF\u20101 levels, and side effects associated with RT were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The baseline GH level decreased from 20.7 (16\u201325.4) \u03bcg\/L to 11.2 (8.3\u201314.1) \u03bcg\/L (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) at 2\u2009years, further dropping to 5.8 (4.99\u20136.61) \u03bcg\/L (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) at 5\u2009years, and to 2.2 (1.66\u20132.74) \u03bcg\/L (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) at 10\u2009years after RT. Rates of patients achieving suppressed GH levels &lt; 1\u2009\u03bcg\/L rose from 9% at 2\u2009years to 25% at 5\u2009years, 42% at 10\u2009years, and 76% at 15\u2009years. IGF\u20101 levels normalized in 5% of participants at 2\u2009years, 14% at 5\u2009years, 38% at 10\u2009years, and 60% at 15\u2009years. After 10\u2009years, 78% of patients experienced hypogonadism, 80% experienced hypothyroidism, and 82% experienced hypocortisolism. Neurological complications were reported in 4% of patients 10\u2009years post\u2010RT, while 4% developed visual impairments and optic neuropathy within 5\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results suggest that conventional RT is an effective long\u2010term management strategy for patients who do not respond adequately to medical therapy or surgery. However, the high incidence of late\u2010onset hypopituitarism must be taken into account.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ije\/9945510","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:19:07Z","timestamp":1763972347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Long\u2010Term Effects of Postoperative Radiotherapy in Acromegaly: Results From a Single\u2010Center Acromegaly Registry in Iran"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-0702","authenticated-orcid":false,"given":"Farzad","family":"Najafipour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Jafarpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4735-1196","authenticated-orcid":false,"given":"Amir","family":"Bahrami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8108-5979","authenticated-orcid":false,"given":"Majid","family":"Mobasseri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9671-6286","authenticated-orcid":false,"given":"Mitra","family":"Niafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-933X","authenticated-orcid":false,"given":"Mostafa","family":"Najafipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-9463","authenticated-orcid":false,"given":"Akbar","family":"Aliasgarzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9402-0544","authenticated-orcid":false,"given":"Naser","family":"Aghamohammadzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-1497","authenticated-orcid":false,"given":"Jalil","family":"Houshyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-209X","authenticated-orcid":false,"given":"Vahideh","family":"Sadra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-8193","authenticated-orcid":false,"given":"Naimeh Mesri","family":"Alamdari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-3-17"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0071-6"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-804169-7.00015-5"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje-21-0216"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-020-09588-z"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-8529(18)30204-4"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb03789.x"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf03344942"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-020-01091-7"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci39375"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1191"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz096"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031199"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(22)00244-3"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-023-01322-7"},{"key":"e_1_2_14_16_2","volume-title":"Diagnosis and Treatment of Acromegaly: An Update. 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