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This study is aimed at comprehensively evaluating the phytochemical composition, fatty acid profile, and multifunctional bioactivities of\n                    <jats:italic>S. brachiata<\/jats:italic>\n                    seeds. Dried powdered\n                    <jats:italic>S. brachiata<\/jats:italic>\n                    seeds were subjected to sequential extraction using hexane (HE), dichloromethane (DE), and methanol (ME) in order. The fatty acid profile of HE was analyzed using GC\u2010MS. Total phenolic content (TPC), total flavonoid content (TFC), condensed tannin content (CTC), and antioxidant activity of each extract were determined. Enzyme inhibitory potential was evaluated against\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase, lipase, angiotensin\u2010converting enzyme, and urease. Anti\u2010inflammatory activity and antibacterial activity were assessed for\n                    <jats:italic>S. brachiata<\/jats:italic>\n                    seed powder extracts. The results revealed that ME has the highest quantities of TPC, TFC, and CTC. GC\u2010MS analysis of HE revealed linoleic acid (53.32%) as the dominant fatty acid, with an unsaturated\u2010to\u2010saturated ratio of 2.36:1, indicating strong nutritional and bioactive potential. ME showed the lowest IC\n                    <jats:sub>50<\/jats:sub>\n                    for DPPH and ABTS radical scavenging assays: 32.13 \u00b1 0.97 and 75.11 \u00b1 2.17\n                    <jats:italic>\u2009\u03bc<\/jats:italic>\n                    g\/mL, respectively. HE expressed a potent inhibition for antidiabetic activity compared to acarbose. The lowest IC\n                    <jats:sub>50<\/jats:sub>\n                    for lipase inhibition among extracts was shown by ME (241.67 \u00b1 24.91\n                    <jats:italic>\u2009\u03bc<\/jats:italic>\n                    g\/mL). DE showed strong antihypertensive activity (78.78\n                    <jats:italic>%<\/jats:italic>\n                    \u00b1 1.08\n                    <jats:italic>%<\/jats:italic>\n                    ) at 0.5\u2009mg\/mL, though less effective than captopril (91.85\n                    <jats:italic>%<\/jats:italic>\n                    \u00b1 1.23\n                    <jats:italic>%<\/jats:italic>\n                    ). HE and DE expressed lower IC\n                    <jats:sub>50<\/jats:sub>\n                    values: 32.40 \u00b1 2.21\u2009and 12.43 \u00b1 1.31\n                    <jats:italic>\u2009\u03bc<\/jats:italic>\n                    g\/mL, respectively, in the urease inhibitory assay, highlighting their higher potency compared to thiourea with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 72.23 \u00b1 3.76\n                    <jats:italic>\u2009\u03bc<\/jats:italic>\n                    g\/mL. DE and ME showed less potency than aspirin in the anti\u2010inflammatory assay. Antibacterial efficacy of\n                    <jats:italic>S. brachiata<\/jats:italic>\n                    seed powder extracts demonstrated a broad spectrum of defense against tested bacteria. Therefore,\n                    <jats:italic>S. brachiata<\/jats:italic>\n                    seeds exhibit multifunctional bioactivities, making them an ideal supplement for fortified foods as well as an effective nutraceutical.\n                  <\/jats:p>","DOI":"10.1155\/ijfo\/2940708","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:04:36Z","timestamp":1775124276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Valorizing\n                    <i>Salicornia brachiata<\/i>\n                    Seeds: A Rich Source of Polyphenols, Essential Fatty Acids, and Therapeutic Bioactivities"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3283-7584","authenticated-orcid":false,"given":"Poornima","family":"Jeewanthi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4245-4759","authenticated-orcid":false,"given":"Nilaksha","family":"Navod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9933-6434","authenticated-orcid":false,"given":"Sanath","family":"Madhushantha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-777X","authenticated-orcid":false,"given":"Renuka","family":"Attanayake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5103-2297","authenticated-orcid":false,"given":"Dinum","family":"Perera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5489-081X","authenticated-orcid":false,"given":"Priyani","family":"Paranagama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.53663\/turjfas.1280239"},{"key":"e_1_2_11_2_2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1079\/9781786394330.0324","volume-title":"Halophytes and Climate Change: Adaptive Mechanisms And Potential Uses","author":"Centofanti T.","year":"2019"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-016-0418-6"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27227954"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods10010119"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-022-01574-0"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods10020410"},{"key":"e_1_2_11_8_2","article-title":"Studies on the Phytochemistry, Spectroscopic Characterization and Antibacterial Efficacy of Salicornia brachiata","volume":"6","author":"Santhanakrishnan D.","year":"2014","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants13040545"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s42269-020-00388-8"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2016.10.005"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2008.1072"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13050596"},{"key":"e_1_2_11_14_2","first-page":"352","article-title":"Antioxidant Activity, Total Phenolics and Flavonoids of Salicornia brachiata Roxb. 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