{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:41:28Z","timestamp":1786117288917,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":217,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hepatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2013associated steatotic liver disease (MASLD) is a common metabolic liver condition primarily managed through lifestyle modification. Obeticholic acid (OCA), a farnesoid X receptor agonist, has shown therapeutic benefits in steatohepatitis, yet its short\u2010term metabolic effects remain unclear. This study compared OCA plus lifestyle modification versus lifestyle intervention alone in adults with MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This quasi\u2010experimental study included 360 adults aged 18\u201360 years with ultrasound\u2010diagnosed MASLD and insulin resistance (HOMA \u2212 IR &gt; 2.0). Patients with diabetes mellitus, viral hepatitis, cirrhosis, advanced fibrosis, ischemic heart disease or LDL \u2212 C &gt; 160\u2009mg\/dL were excluded. Participants received either OCA (10\u2009mg\/day) plus standardised lifestyle modification or lifestyle intervention alone for 3 months. Anthropometric, biochemical and hepatic parameters were evaluated at baseline and follow\u2010up, with ANCOVA performed to adjust for baseline covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline demographic and metabolic characteristics were comparable between groups. After 3 months, the OCA plus lifestyle group demonstrated significantly greater improvements in ALT (36.65 \u00b1 20.57 vs. 48.19 \u00b1 21.35\u2009U\/L;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), fatty liver index (55.99 \u00b1 12.60 vs. 63.08 \u00b1 11.89;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and HEPAMET score (0.33 \u00b1 0.13 vs. 0.41 \u00b1 0.13;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), along with a greater reduction in body weight (77.28 \u00b1 12.07\u2009kg vs. 80.19 \u00b1 12.37\u2009kg;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.024). Postintervention HOMA\u2010IR was significantly lower with OCA plus lifestyle than lifestyle alone (2.46 \u00b1 0.92 vs. 2.96 \u00b1 1.06; mean difference 0.50;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). LDL\u2010C increased significantly in the OCA group (139.50 \u00b1 15.74\u2009mg\/dL vs. 131.96 \u00b1 16.36\u2009mg\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Over 3 months, OCA combined with lifestyle modification improved liver enzymes, steatosis and fibrosis\u2010related surrogate indices, and modestly reduced insulin resistance. Careful lipid monitoring is recommended, and longer term studies are required to clarify the overall metabolic and cardiovascular implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijh\/3306359","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:32:22Z","timestamp":1786023142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Obeticholic Acid Therapy on Insulin Resistance and Metabolic Parameters in Metabolic Dysfunction\u2013Associated Steatotic Liver Disease 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