{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:16:29Z","timestamp":1773011789870,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":355,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hepatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Portal vein thrombosis (PVT) is a vascular liver disorder defined by a thrombus in the portal vein or its intrahepatic branches. Computed tomography (CT) and upper endoscopy are, respectively, used to monitor for PVT progression and portal hypertensive complications. A noninvasive modality\u2014spleen stiffness (SS)\u2014has shown promise in identifying clinically significant portal hypertension (CSPH) in cirrhosis. It is unknown whether SS demonstrates any correlation with PVT, a condition associated with prehepatic portal hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The primary aim was to determine the association between SS and the presence of PVT. The secondary aim was to evaluate the association between SS and portal hypertension\u2013related complications among patients with PVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study was undertaken at two regional hospitals in Hong Kong from January 2023 to March 2024. Patients were identified via CT and allocated to either the PVT or non\u2010PVT group. Chronic liver disease was an exclusion criterion for both groups. SS was assessed using transient elastography within 3 months of PVT diagnosis. Demographic, clinical, and laboratory data were collected within 3 months of PVT diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 46 patients with PVT (median age, 69 years; interquartile range [IQR], 62\u201378; 74% male) were compared with 45 controls. Both SS and liver stiffness (LS) were significantly higher in the PVT cohort than in controls (SS: 27.9 [IQR, 19.5\u201342.8] vs. 16.9\u2009kPa [IQR, 13.6\u201321.2],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001; LS: 6.0 [IQR, 4.8\u20138.6] vs. 4.6\u2009kPa [IQR, 3.7\u20135.9],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Among patients with PVT, those with portal hypertension\u2013related complications demonstrated markedly elevated SS compared with those without complications (77.7 [IQR, 47.2\u201385.0] vs. 24.4\u2009kPa [IQR, 18.9\u201337.1],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Furthermore, SS values increased in proportion to the anatomical extent of PVT involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated SS was observed in patients with PVT, particularly in those with PVT\u2010induced portal hypertension. Large\u2010scale, prospective studies are warranted to confirm the association between SS and PVT and to establish its potential role in noncirrhotic portal hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijh\/5531253","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T16:19:37Z","timestamp":1766420377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Noninvasive Assessment of Prehepatic Portal Hypertension: Pilot Data on Spleen Stiffness in Portal Vein Thrombosis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8281-991X","authenticated-orcid":false,"given":"Kelly Tin Long","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0785-0707","authenticated-orcid":false,"given":"Oi Ling","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0553-8218","authenticated-orcid":false,"given":"Yin Yee","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5328-8533","authenticated-orcid":false,"given":"Siu Wing Lawrence","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31646"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.025"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.040"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406223231206223"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13243"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.04.023"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.09.138"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10062-w"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.018"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn.2019.09.05"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v10.i10.731"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000029389"},{"key":"e_1_2_11_13_2","first-page":"S1893","article-title":"EP57: Spleen Stiffness Measurement by Transient Elastography in Non-Cirrhotic Portal Vein Thrombosis","volume":"169","author":"Chan K. 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