{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:50:55Z","timestamp":1791611455633,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":281,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hepatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hepatocellular carcinoma (HCC) is a leading cause among cancer\u2010related deaths. HCC progression is linked to alteration of lipid metabolism. Lectin\u2010like oxidized low\u2010density lipoprotein receptor\u20101 (LOX\u20101), a receptor for oxidized low\u2010density lipoproteins (ox\u2010LDLs), and its splicing isoform LOX\u20101\n                      <jats:italic>\u0394<\/jats:italic>\n                      4 have been recently identified and linked to tumor aggressiveness, but their role in HCC carcinogenesis is largely unexplored. The present study is aimed at investigating and comparing the role of LOX\u20101 and its splicing variant LOX\u20101\n                      <jats:italic>\u0394<\/jats:italic>\n                      4 in HCC progression and chemoresistance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed in vivo evaluation of LOX\u20101 expression on HCC tissue samples by immunohistochemistry and in vitro transfection studies on HCC cell line HepG2 to verify the involvement of LOX\u20101 and its variant LOX\u20101\n                      <jats:italic>\u0394<\/jats:italic>\n                      4 expression in cell proliferation and chemoresistance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Total LOX\u20101 expression correlated with higher tumor grade in HCC tissue samples. LOX\u20101\n                      <jats:italic>\u0394<\/jats:italic>\n                      4 transfection significantly increased proliferation, enhanced doxorubicin resistance, upregulated p21\n                      <jats:sup>Cip1\/Waf1<\/jats:sup>\n                      , p27\n                      <jats:sup>Kip1<\/jats:sup>\n                      , and Cyclin D1, and downregulated p53 expression. LOX\u20101\n                      <jats:italic>\u0394<\/jats:italic>\n                      4 also increased acetyl\u2010histone H4 expression, suggesting DNA acetylation\u2010driven transcription. Both LOX\u20101 and LOX\u20101\n                      <jats:italic>\u0394<\/jats:italic>\n                      4 transfections were associated with increased p62 and vimentin expression, alongside decreased LC3B\u2010II levels, with LOX\u20101\n                      <jats:italic>\u0394<\/jats:italic>\n                      4 exhibiting a more marked modulation of LC3B.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      LOX\u20101\n                      <jats:italic>\u0394<\/jats:italic>\n                      4 isoform appears to exert a more pronounced influence than full\u2010length LOX\u20101 on HCC progression\u2010related features in vitro. LOX\u20101\n                      <jats:italic>\u0394<\/jats:italic>\n                      4 appears to impact nonviral HCC progression more than LOX\u20101 in vitro. These preliminary findings suggest this axis as a potential future therapeutic target, though in vivo validation remains essential.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijh\/5704085","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:23:39Z","timestamp":1791609819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LOX\u20101 and Its Splicing Variant LOX\u20101\n                    <i>\u0394<\/i>\n                    4 Differently Influence Hepatocellular Carcinoma Cell Progression and Aggressiveness"],"prefix":"10.1155","volume":"2026","author":[{"given":"Martina","family":"Puzzuoli","sequence":"first","affiliation":[{"name":"Dept. of Biomedicine and Prevention University of Rome \u201cTor Vergata\u201d  Rome Italy  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