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However, their use is often limited by the risk of hepatotoxicity, a potentially severe side effect. Among the factors implicated in drug\u2010induced liver injury, cytochrome P450 2E1 (CYP2E1) is emerging as a key enzyme in the pathogenesis of hepatotoxicity. CYP2E1 is involved in the oxidative metabolism of many xenobiotics, including AT drugs, and is known to produce reactive oxygen species (ROS) during the metabolism process, which can lead to cellular damage. This review investigates the potential role of CYP2E1 in the mechanisms behind AT drug\u2013induced hepatotoxicity and explores the biochemical and molecular pathways through which CYP2E1 might contribute to liver injury. Genetic polymorphisms in the CYP2E1 gene, which affect its activity, may also play a role in individual susceptibility to AT drug\u2013induced hepatotoxicity. This review also deals with how multifactorial interactions including genetic polymorphisms in CYP2E1, N\u2010acetyl transferase 2 (NAT2), and glutathione\u2010S\u2010transferase (GST), as well as factors such as drug\u2013drug interactions, nutritional status, coexisting infections (e.g., hepatitis B\/C), and alcohol consumption collectively modulate individual susceptibility to AT drug\u2013induced hepatotoxicity. 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