{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:00:44Z","timestamp":1782853244859,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":139,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003969","name":"Ministry of Health and Medical Education","doi-asserted-by":"publisher","award":["31309304"],"award-info":[{"award-number":["31309304"]}],"id":[{"id":"10.13039\/501100003969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Hypertension is the most prominent established risk factor for adverse cardiovascular outcomes. The influence of hypertension in combination with other major cardiovascular disease risk factors (CVD\u2010RFs) on mortality and cardiovascular events has not been fully comprehended yet due to their overlapping and interconnected nature. This study was conducted to evaluate the impact of CVD\u2010RFs quantity on the occurrence of cardiovascular events, CVD\u2010related mortality, and all\u2010cause mortality rates in hypertensive patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design and Method:<\/jats:bold>\n                    In a secondary analysis of the Isfahan Cohort Study, demographic information, anthropometric measures, and laboratory results of participants were extracted. During the 15\u2009years of follow\u2010up, all\u2010cause mortality, CVD\u2010related mortality, and the occurrence of nonfatal cardiovascular events were assessed by separate panels of experts. Data analysis was performed using Cox proportional hazard models to estimate adjusted hazard ratios (HRs) among normotensive and hypertensive individuals in two subgroups of 3 CVD\u2010RFs and\u2265\u20093 CVD\u2010RFs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Among 5432 eligible participants, hypertensive patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091509) had 1.3, 2, and 1.4 times higher HRs for all\u2010cause mortality, CVD\u2010related mortality, and nonfatal cardiovascular events, respectively. Compared to the normotensives, HRs for the mentioned outcomes were 1.2, 1.7, and 1.3 for hypertensive participants with &lt;\u20093 CVD\u2010RFs and 1.7, 3.4, and 2.3 for hypertensive participants with\u2265\u20093 CVD\u2010RFs. These rises were shown to be highly significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) for CVD\u2010related mortality and nonfatal cardiovascular events in hypertensives with \u2265\u20093 CVD\u2010RFs compared with hypertensives with &lt;\u20093 CVD\u2010RFs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Hypertension alone or combined with other CVD\u2010RFs increases the chance of all\u2010cause mortality, CVD\u2010related mortality, and nonfatal cardiovascular events. Rises in the quantity of other CVD\u2010RFs (specifically to\u2265\u20093) result in highly significant increases in fatal and nonfatal cardiovascular events. Therefore, to reduce mortality and cardiovascular events, hypertensive patients should be thoroughly evaluated for coexisting CVD\u2010RFs, aiming to limit the synergistic effects of multiple CVD\u2010RFs by properly managing modifiable RFs.\n                  <\/jats:p>","DOI":"10.1155\/ijhy\/3743691","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T01:18:09Z","timestamp":1747790289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of Cardiovascular Events in Hypertensive Patients Based on the Quantity of Major Risk Factors According to the Isfahan Cohort Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-5558","authenticated-orcid":false,"given":"Masoumeh","family":"Sadeghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-7742","authenticated-orcid":false,"given":"Reza","family":"Shokrani Foroushani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-5187","authenticated-orcid":false,"given":"Erfan","family":"Sabouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6901-3665","authenticated-orcid":false,"given":"Mohammad","family":"Talaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6828-2169","authenticated-orcid":false,"given":"Nizal","family":"Sarrafzadegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6841-4830","authenticated-orcid":false,"given":"Shahram","family":"Oveisgharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5831-2838","authenticated-orcid":false,"given":"Erfan","family":"Sheikhbahaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-0431","authenticated-orcid":false,"given":"Hamidreza","family":"Roohafza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)01330-1"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)60685-1"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-6-200503150-00005"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(98)10279-9"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(04)17018-9"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.116.07381"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx760"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.15171\/jcvtr.2017.27"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr205"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.759"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.33.5.1130"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1089"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2008.16"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200106000-00021"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.03.021"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.99"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000150859.47929.8e"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/s1368980008004230"},{"key":"e_1_2_13_20_2","first-page":"1073","article-title":"The Iranian Version of International Physical Activity Questionnaire (IPAQ) in Iran: Content and Construct Validity, Factor Structure, Internal Consistency and Stability","volume":"18","author":"Moghaddam M. B.","year":"2012","journal-title":"World Applied Sciences Journal"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.0b013e318296aeca"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e31826e1058"},{"key":"e_1_2_13_23_2","first-page":"138","article-title":"Incidence of Cardiovascular Diseases in an Iranian Population: The Isfahan Cohort Study","volume":"16","author":"Talaei M.","year":"2013","journal-title":"Archives of Iranian Medicine"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(08)60655-8"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018742"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.054"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hipert.2022.02.002"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56040182"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.086660"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.065490"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.054"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs475"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.01.014"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153310"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120255"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-017-0959-2"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.113905"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl361"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2022.100342"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154961"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.008"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(10)60484-9"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02304"},{"key":"e_1_2_13_44_2","first-page":"596","article-title":"Rate and Risk of All Cause Mortality Among People With Known Hypertension in a Rural Community of Southern Kerala, India: The Results From the Prolife Cohort","volume":"5","author":"Kuriakose A.","year":"2014","journal-title":"International Journal of Preventive Medicine"}],"container-title":["International Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijhy\/3743691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ijhy\/3743691","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijhy\/3743691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:05:07Z","timestamp":1782849907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ijhy\/3743691"}},"subtitle":[],"editor":[{"given":"Tomohiro","family":"Katsuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/ijhy\/3743691"],"URL":"https:\/\/doi.org\/10.1155\/ijhy\/3743691","archive":["Portico"],"relation":{},"ISSN":["2090-0384","2090-0392"],"issn-type":[{"value":"2090-0384","type":"print"},{"value":"2090-0392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3743691"}}