{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:00:43Z","timestamp":1782853243614,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":127,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To assess serum magnesium mean levels in pregnant women with severe preeclampsia at three landmarks: prior to MgSO\n                    <jats:sub>4<\/jats:sub>\n                    intake, 30\u2009min, and 6\u2009h postintake of loading dose plus maintenance dose.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methodology:<\/jats:bold>\n                    This cross\u2010sectional study collected blood samples over a timeframe of 0\u20136\u2009h from 64 pregnant women diagnosed with severe preeclampsia who were receiving MgSO\n                    <jats:sub>4<\/jats:sub>\n                    therapy at the emergency management department of Hung Vuong Hospital, Vietnam, in the period of November 2023 to April 2024. Serum magnesium levels were measured three times in the timeframe.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Prior to MgSO\n                    <jats:sub>4<\/jats:sub>\n                    intake, the serum magnesium mean level was 0.75\u2009\u00b1\u20090.13\u2009mmol\/L. At 30\u2009min postloading dose intake plus maintenance, the level increased to 1.65\u2009\u00b1\u20090.32\u2009mmol\/L, and at 6\u2009h, 1.6\u2009\u00b1\u20090.34\u2009mmol\/L, where 17.2% of patients had a serum magnesium level of 2\u2009mmol\/L or higher.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    There were no eclampsia incidents in patients with severe preeclampsia treated with a regimen of a loading dose of 4.5\u2009g MgSO\n                    <jats:sub>4<\/jats:sub>\n                    followed by a 1\u2009g\u2010hourly maintenance. Nevertheless, about 17% of participants achieved the desired threshold of 2\u2009mmol\/L, indicating a need for additional research to refine the loading and maintenance doses of MgSO\n                    <jats:sub>4<\/jats:sub>\n                    for better management of severe preeclampsia in Vietnamese women.\n                  <\/jats:p>","DOI":"10.1155\/ijhy\/5541651","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T01:18:57Z","timestamp":1746753537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Serum Magnesium Mean Levels at Pre\u2010 and Postmagnesium Sulfate Uptake for Eclampsia Prevention: A Cross\u2010Sectional Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-9770","authenticated-orcid":false,"given":"Tuan Minh","family":"Vo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1659-5445","authenticated-orcid":false,"given":"Du","family":"Van Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dat Quoc","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toan Thi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo Ha","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Tan","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liem Ba","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.09.011"},{"key":"e_1_2_11_2_2","unstructured":"WHO Guidelines 2011 World Health Organization https:\/\/www.who.int\/publications\/i\/item\/9789241548335."},{"key":"e_1_2_11_3_2","first-page":"131","article-title":"The Use of the Magnesium Ion in the Management of Eclamptogenic Toxemias","volume":"100","author":"Pritchard J. A.","year":"1955","journal-title":"Surgery Gynecology & Obstetrics"},{"key":"e_1_2_11_4_2","volume-title":"Cardiovascular and Respiratory Disorders","author":"Casanova R.","year":"2019"},{"key":"e_1_2_11_5_2","first-page":"269","article-title":"Management of Preeclampsia: Antihypertensive Drugs and Magnesium Sulfate","author":"Thuy Le Tran","year":"2020","journal-title":"Obstetrics and Gynecology Textbook"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003018"},{"key":"e_1_2_11_7_2","first-page":"711","article-title":"Clinical Management of the Preeclampsia Syndrome","author":"Cunningham F. G.","year":"2022","journal-title":"Williams Obstetrics"},{"key":"e_1_2_11_8_2","unstructured":"HungV. H. Number of Severe Preeclampsia Cases Admitted to the Emergency Department 2022 https:\/\/drive.google.com\/file\/d\/1xB_thsJ8oaQG_GM5IRzIwuP8FohK6w7u\/preview."},{"key":"e_1_2_11_9_2","unstructured":"Hung Vuong Hospital Guidelines for the Diagnosis and Treatment of Gestational Hypertension-Issued With Decision No. 253\/Q\u0110-BVHV Dated March 6 2020 2020 https:\/\/drive.google.com\/file\/d\/1xB_thsJ8oaQG_GM5IRzIwuP8FohK6w7u\/preview."},{"key":"e_1_2_11_10_2","unstructured":"Hung Vuong Hospital Diagnosis and Treatment of Gestational Hypertension-Issued With Decision No. 5248\/Q\u0110-BVHV Dated September 20 2023 2023 https:\/\/drive.google.com\/drive\/u\/1\/recent."},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000016779"},{"key":"e_1_2_11_12_2","unstructured":"Ministry of Health of Vietnam Guidelines for the Diagnosis of Preeclampsia\u2013Eclampsia 2015 29\u201334 https:\/\/thuvienphapluat.vn\/van-ban\/The-thao-Y-te\/Quyet-dinh-315-QD-BYT-2015-tai-lieu-Huong-dan-chan-doan-dieu-tri-cac-benh-san-phu-khoa-265421.aspx."},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1993.tb00398.x"},{"key":"e_1_2_11_14_2","first-page":"607","article-title":"Intravenous and Intramuscular Magnesium Sulphate Regimens in Severe Pre-eclampsia","volume":"84","author":"Chissell S.","year":"1994","journal-title":"South African Medical Journal"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349509024381"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641950902928704"},{"key":"e_1_2_11_17_2","first-page":"233","article-title":"A Study on Serum Magnesium Levels in Pregnant Women With Preeclampsia and Eclampsia Treated With Magnesium Sulfate at Tu Du Hospital","volume":"1","author":"Hoang Y. 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