{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:19:16Z","timestamp":1783714756174,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":91,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hypertension"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertension is a risk factor for cardiovascular disease (CVD). Pomegranates are fruits with a high phenol content that have an antihypertensive effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This randomized postprandial pilot study evaluated microencapsulated pomegranate juice (MPJ) as a natural antihypertensive agent in patients with mild hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The content of phenols, flavonoids, anthocyanins, and antioxidant activity in fresh pomegranate juice (FPJ) and MPJ was determined. Subsequently, the postprandial antihypertensive effect was evaluated in recruited participants who consumed approximately a 480\u2009kcal breakfast. Four experimental groups with five participants each were evaluated: FPJ, 150\u2009mL fresh juice; MPJ, 20\u2009g MPJ; the participant\u2019s usual drug (AH); and 150\u2009mL water (W) with breakfast. Each participant\u2019s blood pressure (BP) was measured before and after breakfast at 30, 60, 90, and 120\u2009min. Changes in BP values were evaluated as a function of time using generalized linear models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MPJ contained the highest content of phenols (14.84\u2009\u00b1\u20090.03\u2009mg gallic acid equivalent\/g lyophilized FPJ) and flavonoids (9.20\u2009\u00b1\u20090.50\u2009mg quercetin equivalent\/g lyophilized FPJ) compared to FPJ; the latter contained a higher content of anthocyanins (3.06\u2009\u00b1\u20090.009\u2009mg cyanidin 3\u2010glucoside\/g lyophilized FPJ) and had higher antioxidant capacity. In systolic BP, AH showed significant reductions at 60\u2013120\u2009min. Several statistically significant differences in diastolic pressure were observed: MPJ at 30\u2013120\u2009min and FPJ and AH groups at 60\u2013120\u2009min. FPJ exerted an effect similar to AH at 90\u2009min.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest a moderate postprandial antihypertensive effect of MPJ when used as an adjunct to pharmacological treatment. However, the findings do not support its use as a replacement for antihypertensive therapy.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT07017296\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijhy\/7665540","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:55:46Z","timestamp":1775123746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postprandial Antihypertensive Evaluation of Microencapsulated Pomegranate Juice in Women With Mild Hypertension: A Randomized Pilot Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-6904","authenticated-orcid":false,"given":"Gabriel","family":"Betanzos-Cabrera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-8584","authenticated-orcid":false,"given":"Perfecta","family":"Cabrera-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-4409","authenticated-orcid":false,"given":"H\u00e9ctor Enrique","family":"Fabella-Illescas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-1050","authenticated-orcid":false,"given":"Leonardo 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