{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:10:37Z","timestamp":1777705837694,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":332,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Coronavirus disease\u201019 (COVID\u201019) is correlated to a severe condition caused by a cytokine storm during which numerous proinflammatory cytokines, including interleukin\u20106 (IL\u20106) are released. IL\u20106 is a critical driver in the COVID\u201019 inflammatory state, and the inhibition is considered a potential treatment approach to prevent serious complications. Meanwhile, <jats:italic>Melaleuca cajuputi<\/jats:italic> is a plant with antibacterial, antiviral, anti\u2010inflammatory, and antioxidant activities. Therefore, this aimed to investigate the anti\u2010inflammatory potential of <jats:italic>M. cajuputi<\/jats:italic> in silico. Extraction of leaves was conducted by using 96% ethanol, followed by fractionation to obtain active compounds. Subsequently, LC\/MS and GC\/MS analyses were performed to obtain active compound profiling. Protein\u2010protein interaction (PPI), as well as molecular docking and dynamic analyses, were performed to examine interaction of active compounds of <jats:italic>M. cajuputi<\/jats:italic> with IL\u20106. The results showed that 30 protein nodes played a significant role in COVID\u201019 cytokine storm and eight active compounds had interactions with IL\u20106. Among the active compounds, pinostrobin chalcone had the best delta G interaction with IL\u20106. In conclusion, <jats:italic>M. cajuputi<\/jats:italic> has potential activity as an anti\u2010inflammatory agent against COVID\u201019.<\/jats:p>","DOI":"10.1155\/ijin\/5568294","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T10:40:24Z","timestamp":1732790424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protein Interaction Analysis and Molecular Simulation of the Anti\u2010Inflammatory Activities in <i>Melaleuca cajuputi<\/i> Extract Against COVID\u201019"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3755-0858","authenticated-orcid":false,"given":"Agustyas","family":"Tjiptaningrum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-3185","authenticated-orcid":false,"given":"Intanri","family":"Kurniati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8120-3138","authenticated-orcid":false,"given":"Fadilah","family":"Fadilah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5276-7997","authenticated-orcid":false,"given":"Tiwuk","family":"Susantiningsih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-7121","authenticated-orcid":false,"given":"Aisyah Fitriannisa","family":"Prawiningrum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8939-3921","authenticated-orcid":false,"given":"Wahyu Dian","family":"Utari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1108-0600","authenticated-orcid":false,"given":"Linda","family":"Erlina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17082690"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00028-20"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.05.009"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41479-021-00092-9"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14364"},{"key":"e_1_2_11_6_2","volume-title":"COVID-19 Cytokines and the Hyperactive Immune Response: Synergism of TNF-\u03b1 and IFN-\u03b3 in Triggering Inflammation, Tissue Damage, and Death","author":"Karki R.","year":"2020"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02037"},{"key":"e_1_2_11_8_2","volume-title":"The Impacts of Anti-inflammatory Agents on COVID-19 Cytokine Storm","author":"Chukwuma I. 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