{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:56:37Z","timestamp":1772981797846,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":171,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023174","name":"Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023174","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Psoriasis is a chronic inflammatory skin disease that exhibits a strong association with metabolic syndrome (MetS). The involvement of various proinflammatory cytokines in MetS is thought to play a critical role in the pathogenesis of psoriasis. This study aims to evaluate the impact of MetS on immunological markers (IL\u201017, IL\u201023, and FOXP3+ regulatory T cells), disease severity, and quality of life (QoL) among patients with psoriasis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This cross\u2010sectional study involved 42 psoriasis patients, divided into two groups: 29 without MetS (Pso) and 13 with MetS (Pso\u2010MetS). Clinical parameters such as blood pressure, fasting blood glucose, and triglyceride levels were measured. Immunological markers (IL\u201017, IL\u201023, and FOXP3+) were analyzed using ELISA. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI), and QoL was evaluated with the Dermatology Life Quality Index (DLQI).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The Pso\u2010MetS group was significantly older than the Pso group (\n                    <jats:italic>p<\/jats:italic>\n                    value\u2009=\u20090.003). Higher systolic (\n                    <jats:italic>p<\/jats:italic>\n                    value &lt; 0.001), fasting glucose (\n                    <jats:italic>p<\/jats:italic>\n                    value\u2009=\u20090.002), and triglycerides (\n                    <jats:italic>p<\/jats:italic>\n                    value &lt; 0.001) were observed in the Pso\u2010MetS group. Lower HDL observed in the Pso\u2010MetS group (\n                    <jats:italic>p<\/jats:italic>\n                    value\u2009=\u20090.004). FOXP3+ expression was significantly lower in the Pso\u2010MetS group (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02), while waist circumference, diastolic blood pressure, IL\u201017, IL\u201023, PASI, and DLQI scores levels showed no significant differences.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    MetS is associated with immune dysregulation, evidenced by reduced FOXP3+ expression in psoriasis patients. Further studies are needed to explore the immunological link between psoriasis and MetS.\n                  <\/jats:p>","DOI":"10.1155\/ijin\/5855171","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T03:33:57Z","timestamp":1750476837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Metabolic Syndrome on Immune Regulation (IL\u201017, IL\u201023, and FOXP3+), Psoriasis Severity, Flare Frequency, and Quality of Life in Psoriasis Patients: A Cross\u2010Sectional Study"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3625-6142","authenticated-orcid":false,"given":"Flora Ramona Sigit","family":"Prakoeswa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7062-9790","authenticated-orcid":false,"given":"Faradiba","family":"Maharani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0786-5720","authenticated-orcid":false,"given":"Saiful","family":"Hidayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winda Atika","family":"Sari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0879-586X","authenticated-orcid":false,"given":"Triasari","family":"Oktavriana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3232-095X","authenticated-orcid":false,"given":"Cita Rosita Sigit","family":"Prakoeswa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0940-8689","authenticated-orcid":false,"given":"Menul Ayu","family":"Umborowati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7341-3939","authenticated-orcid":false,"given":"Ratih","family":"Pramuningtyas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5203-7811","authenticated-orcid":false,"given":"Rochmadina Suci","family":"Bestari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0742-6023","authenticated-orcid":false,"given":"Riandini","family":"Aisyah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7623-6982","authenticated-orcid":false,"given":"Erika Diana","family":"Risanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-3856","authenticated-orcid":false,"given":"Listiana Masyita","family":"Dewi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilham Hafizha Maulana","family":"Anam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"key":"e_1_2_13_1_2","volume-title":"Psoriasis","author":"Nair P. A.","year":"2024"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/IJD.14864"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ANNRHEUMDIS-2018-214065"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/BMJOPEN-2018-028116"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.20473\/BIKK.V33.3.2021.173-181"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.IJRMS20232773"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.365"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.52099"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.72462"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18044"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13175240"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0889-6"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.193908"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.15294\/higeia.v6i1.50196"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.64.04.368"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13535"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.26911\/JEPUBLICHEALTH.2023.08.01.10"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.23917\/pharmacon.v18i2.16299"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7352637"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14161774"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2019.0092"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20186397"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.23917\/biomedika.v13i2.12881"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03174-2"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S422355"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.23917\/biomedika.v13i1.13544"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.2012.0025"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1159-3"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0293327"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.06.003"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.06.020"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8879809"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.139"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.5455\/MEDARH.2014.68.236-238"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3069521"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001379"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ART.39031"}],"container-title":["International Journal of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijin\/5855171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ijin\/5855171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijin\/5855171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:29:35Z","timestamp":1772958575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ijin\/5855171"}},"subtitle":[],"editor":[{"given":"Mariusz","family":"Sikora","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/ijin\/5855171"],"URL":"https:\/\/doi.org\/10.1155\/ijin\/5855171","archive":["Portico"],"relation":{},"ISSN":["2090-8040","2042-0099"],"issn-type":[{"value":"2090-8040","type":"print"},{"value":"2042-0099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5855171"}}