{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:48:40Z","timestamp":1791618520589,"version":"4.3.4"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":281,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    It is supposed that the primary or secondary dysfunction of macrophages may play an essential role in the pathogenesis of endometriosis. It is postulated that macrophage\u2010derived cytokines and signaling molecules, such as IL\u20101 (interleukin), IL\u20106, and IL\u201012, tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interferon\u2010gamma (IFN\u2010\u03b3), and MCP\u20101 (monocyte chemoattractant protein) may be involved in the process of endometriosis formation. This pilot study included 47 patients who underwent diagnostic\u2013therapeutic laparoscopy at the II Department of Gynecology, Medical University of Lublin, Poland. Peritoneal fluid was obtained from patients in both the reference and study groups. The number and viability of the cells were assessed. The cells were labeled with monoclonal antibodies and assessed using flow cytometry. Interleukins of macrophage origin in the peritoneal fluid were determined using the enzyme\u2010linked immunosorbent assay (ELISA) test. The peritoneal fluid showed fundamental changes in the concentration of the studied cytokines. We recorded the peritoneal fluid volume for each patient (median \u223c5\u2009mL in the endometriosis group vs. \u223c4\u2009mL in the reference group) and noted that a larger volume could dilute cytokine levels; cytokine concentrations were thus interpreted per mL of fluid. More than twice as high median IL\u201012 levels were detected in women in the reference group than in the study group. High levels of IL\u20101\u03b1 and low levels of IL\u201012 in the study group compared to the reference group suggest an immunological component in the etiopathogenesis of endometriosis, although this pilot, exploratory study (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200947) cannot establish this relationship definitively. All endometriosis cases were laparoscopically confirmed, but histopathological confirmation was obtained in only 20 of 28 cases (71.4%); the remaining 8 patients had superficial Stage I lesions that were not biopsied. This study aimed to assess the concentrations of IL\u20101\u03b1 and IL\u201012 in the PF of women with endometriosis compared to those with idiopathic infertility.\n                  <\/jats:p>","DOI":"10.1155\/ijin\/6669619","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:55:56Z","timestamp":1791615356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Concentration of Macrophage\u2010Derived IL\u20101\u03b1 and IL\u201012 in the Peritoneal Fluid of Patients With Endometriosis: A Pilot Case\u2013Control Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0195-9005","authenticated-orcid":false,"given":"Monika","family":"Kope\u0107","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology and Pregnancy Pathology Independent Public Health Care Department in \u0141uk\u00f3w  \u0141uk\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Wojta\u015b","sequence":"additional","affiliation":[{"name":"II Chair and Department of Gynecology Medical University of Lublin  Lublin 20-954 Poland  umlub.pl"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-8287","authenticated-orcid":false,"given":"Aleksandra","family":"Kami\u0144ska","sequence":"additional","affiliation":[{"name":"II Chair and Department of Gynecology Medical University of Lublin  Lublin 20-954 Poland  umlub.pl"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5557-7892","authenticated-orcid":false,"given":"Micha\u0142","family":"Kos","sequence":"additional","affiliation":[{"name":"II Chair and Department of Gynecology Medical University of Lublin  Lublin 20-954 Poland  umlub.pl"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2300-3266","authenticated-orcid":false,"given":"Jan","family":"Kotarski","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Cancer Diagnostics and Immunology Medical University in Lublin  Lublin 20-093 Poland  umlub.pl"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Grochowska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Pregnancy Pathology Independent Public Health Care Department in \u0141uk\u00f3w  \u0141uk\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-9110","authenticated-orcid":false,"given":"Katarzyna Dos Santos","family":"Szewczyk","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Medical University of Lublin  Lublin 20-093 Poland  umlub.pl"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-2086","authenticated-orcid":false,"given":"Marek","family":"Gogacz","sequence":"additional","affiliation":[{"name":"II Chair and Department of Gynecology Medical University of Lublin  Lublin 20-954 Poland  umlub.pl"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14161822"},{"key":"e_1_2_12_2_2","volume-title":"Endometriosis; StatPearls Publishing: Treasure Island","author":"Tsamantioti E. S.","year":"2021"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/0167482x.2019.1659775"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1676103"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9010054"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2021.0021"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17103641"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5760959"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061381"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225615"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111700"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012419-032654"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90598-6"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236008"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094370"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/pr9122229"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.03.017"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8879"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245879"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.07.004"},{"key":"e_1_2_12_21_2","first-page":"58","article-title":"Ascitic Fluid Analysis in the Differential Diagnosis of Ascites: Focus on Cirrhotic Ascites","volume":"2","author":"Huang L. L.","year":"2014","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_12_22_2","first-page":"1","article-title":"Mass Cytometry Analysis Reveals a Distinct Immune Environment in Peritoneal Fluid in Endometriosis: a Characterization Study","volume":"18","author":"Guo M.","year":"2020","journal-title":"BMC Medicine"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2916070"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105539"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-010-9321-x"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12122867"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809050903"},{"key":"e_1_2_12_28_2","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0015-0282(02)03082-0","article-title":"Spontaneous and Stimulated Secretion of Monocyte Chemotactic protein-1 and Macrophage Migration Inhibitory Factor by Peritoneal Macrophages in Women with and Without Endometriosis","volume":"77","author":"Akoumen A.","year":"2022","journal-title":"Fertility and Sterility"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2010.010048"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.5603\/gp.a2022.0096"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00007"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30787-x"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1396000"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci181839"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.5603\/gpl.101419"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.2147\/ijwh.s467041"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13462"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa017"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40828-022-00163-4"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.12703\/p6-13"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.041"},{"key":"e_1_2_12_42_2","doi-asserted-by":"crossref","unstructured":"ZondervanK. T. BeckerC. M. MissmerS. A. andEndometriosis New England Journal of Medicine 2020 382 1244\u20131256.","DOI":"10.1056\/NEJMra1810764"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12227176"},{"key":"e_1_2_12_44_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1600-0897.2010.00920.x","article-title":"The Peritoneal Leptin, MCP-1 and TNF-\u03b1 in the Pathogenesis of endometriosis-associated Infertility","volume":"65","author":"Thao Y.","year":"2011","journal-title":"American Journal of Reproductive Immunology"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1134663"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910792"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3175394"},{"key":"e_1_2_12_48_2","first-page":"953","article-title":"Macrophage-Conditioned Media Enhance Endometrial Stromal Cell Proliferation in Vitro","volume":"164","author":"Olive D. L.","year":"1991","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-5-1044"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90356-n"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)54660-3"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.37349\/ei.2022.00062"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180111093547"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1080\/0962935031000134842"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.081011"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(96)70034-0"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1998.tb00347.x"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.11.060"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(00)01538-7"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfss.2022.09.004"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1999.tb00082.x"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.03.013"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1359182"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S421389"}],"container-title":["International Journal of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijin\/6669619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ijin\/6669619","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijin\/6669619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:55:59Z","timestamp":1791615359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ijin\/6669619"}},"subtitle":[],"editor":[{"given":"Newman","family":"Osafo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ijin\/6669619"],"URL":"https:\/\/doi.org\/10.1155\/ijin\/6669619","archive":["Portico"],"relation":{},"ISSN":["2090-8040","2042-0099"],"issn-type":[{"value":"2090-8040","type":"print"},{"value":"2042-0099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6669619"}}