{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:57:45Z","timestamp":1788904665533,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":342,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["4001903"],"award-info":[{"award-number":["4001903"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Interleukin\u201017 (IL17) plays a crucial role in the development of psoriatic plaques, making it a valuable therapeutic target. Recently, aptamers have been identified as promising candidates for inhibiting the biological activity of biomolecules. Despite these advantages, their applications are limited due to negative charge, small size, and lower affinity compared to monoclonal antibodies. To overcome these limitations, in this study, we assessed the therapeutic effects of the gold nanoparticle (AuNPs)\u2010conjugated anti\u2010IL17 single\u2010stranded DNA aptamer in the imiquimod\u2010induced C57BL\/6 psoriasis animal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Hydrogel\u2010containing anti\u2010IL17A aptamer (M2) or aptamer\u2010conjugated AuNPs were applied topically to the dorsal skin of the C57BL\/6 mice 10\u2009min before imiquimod treatment for 5 consecutive days. Psoriasis lesions and skin tissue sections were evaluated using the modified psoriasis area severity index (PASI) score and histology. The mRNA expression levels of inflammatory factors, including\n                      <jats:italic>IL17A, Interleukin1\u03b2 (IL1\u03b2)<\/jats:italic>\n                      , and S100 calcium\u2010binding protein A9 (\n                      <jats:italic>S100A9<\/jats:italic>\n                      ), were assessed using reverse transcription\u2010quantitative polymerase chain reaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cumulative modified PASI score, as well as\n                      <jats:italic>IL17A, IL1\u03b2,<\/jats:italic>\n                      and\n                      <jats:italic>S100A9<\/jats:italic>\n                      mRNA expression levels, showed a significant decrease in the mice treated with anti\u2010IL17A aptamer and anti\u2010IL17A aptamer\u2010conjugated AuNPs in comparison to the imiquimod group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The combination of anti\u2010IL17A aptamer with AuNPs in low concentrations (44\u2009pmol) significantly reduced the thickness of the keratinocyte layer (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In accordance with these results, treatment with anti\u2010IL17A aptamer with AuNPs improved the modified PASI score in the mice skin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings of our study suggest that the anti\u2010inflammatory properties of anti\u2010IL17A (M2) aptamer are amplified when conjugated with AuNPs in the psoriasis\u2010like model. It seems to be a promising alternative for inhibiting the antibodies of IL17.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijin\/9916368","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:21:24Z","timestamp":1765279284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Conjugation of Gold Nanoparticles to the Anti\u2010IL17A Aptamer Improves Anti\u2010Inflammatory Effects of the Aptamer in the Experimental Imiquimod\u2010Induced Psoriasis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1418-2697","authenticated-orcid":false,"given":"Razia","family":"Khorrami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-7400","authenticated-orcid":false,"given":"Saeideh 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