{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:52:41Z","timestamp":1789710761960,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antimicrobial resistance (AMR) is a critical global health threat, with disproportionately high burdens in low\u2010 and middle\u2010income countries. In Indonesia, where antimicrobial stewardship initiatives are still developing, local antibiograms are scarce yet crucial to guide evidence\u2010based empirical therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective descriptive study of cumulative antibiogram data from YARSI Hospital, a tertiary care academic hospital in Jakarta, Indonesia, covering January\u2013December 2024. Analysis followed Clinical and Laboratory Standards Institute (CLSI) M39\u2010A4 guidelines and was restricted to the first clinical isolate per species, patient, and specimen type. Susceptibility data were stratified by Gram classification, specimen source, and care setting, with semester\u2010wise comparisons (January\u2013June vs. July\u2013December).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1782 clinical specimens,\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      predominated among Gram\u2010negative isolates, exhibiting high multidrug resistance with \u2264\u200920% susceptibility to third\u2010generation cephalosporins, particularly in blood and ICU samples.\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                      , the leading respiratory and ICU isolate, retained susceptibility only to amikacin (15%) and trimethoprim\u2013sulfamethoxazole (25%).\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      from urine remained susceptible to ceftazidime (78%), cefepime (81%), meropenem (95%), and amikacin (93%). Gram\u2010positive isolates, including\n                      <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                      and\n                      <jats:italic>Enterococcus faecalis<\/jats:italic>\n                      , were largely susceptible to vancomycin and linezolid, although frequent coagulase\u2010negative staphylococcal bacteremia suggested challenges in aseptic technique.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The persistence of multidrug\u2010resistant\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      and\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      highlights the urgent need for targeted antimicrobial stewardship in Indonesian tertiary hospitals. Routine, stratified antibiogram reporting is essential to guide empirical therapy, inform policy, and curb the progression of AMR.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ijm\/1397226","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:23:41Z","timestamp":1773041021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antimicrobial Resistance Patterns and Cumulative Antibiogram of Clinically Significant Bacteria From a Tertiary Hospital in Indonesia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-4115","authenticated-orcid":false,"given":"Rika","family":"Bur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4785-4774","authenticated-orcid":false,"given":"Muhammad Alifian Remifta","family":"Putra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-0970","authenticated-orcid":false,"given":"Nelly","family":"Puspandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6966-9161","authenticated-orcid":false,"given":"Syukrini","family":"Bahri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9282-3040","authenticated-orcid":false,"given":"Evi","family":"Yuliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3730-7914","authenticated-orcid":false,"given":"Nadya Rashita Valentina","family":"Barus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-6928","authenticated-orcid":false,"given":"Astari Arum","family":"Sari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9783-3178","authenticated-orcid":false,"given":"Talitha Dhia","family":"Fairuza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_13_1_2","volume-title":"Tackling Drug-Resistant Infections Globally: Final Report and Recommendations","author":"O\u2019Neill J.","year":"2016"},{"key":"e_1_2_13_2_2","volume-title":"Global Action Plan on Antimicrobial Resistance","author":"World Health Organization","year":"2015"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70318-9"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-017-0208-x"},{"key":"e_1_2_13_6_2","volume-title":"National Action Plan on Antimicrobial Resistance Control 2020\u20132024","author":"Ministry of Health of the Republic of Indonesia, World Health Organization","year":"2020"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(11)60065-8"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lansea.2024.100414"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2008.02080.x"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/510393"},{"key":"e_1_2_13_11_2","volume-title":"Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data; 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