{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:08:00Z","timestamp":1784531280218,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":199,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/PRR2\/06185\/2025"],"award-info":[{"award-number":["UID\/PRR2\/06185\/2025"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/PRR\/06185\/2025"],"award-info":[{"award-number":["UID\/PRR\/06185\/2025"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/06185\/2025"],"award-info":[{"award-number":["UID\/06185\/2025"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Urinary tract infections (UTIs) are among the most common bacterial infections worldwide. Although Gram\u2010negative bacteria predominate, Gram\u2010positive cocci (GPC) are increasingly recognized as significant uropathogens. This retrospective study analyzed 655 patients with culture\u2010confirmed GPC UTIs in a hospital in Central Portugal (2018\u20132022) to identify predictors of multidrug resistance (MDR). MDR was defined as resistance to three or more antimicrobial classes. The overall MDR prevalence was 83.7%, with\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    spp. showing the highest MDR prevalence (98.2%). Multivariate analysis identified older age as an independent predictor of MDR, whereas\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    and\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    species were associated with significantly lower odds compared to\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    . A temporal increase in MDR risk was observed in 2021 and 2022. Despite the high overall resistance rates observed, oxazolidinones and cyclic lipopeptides retained near\u2010complete activity against all GPC isolates, reinforcing their role as last\u2010line therapeutic options.\n                  <\/jats:p>","DOI":"10.1155\/ijm\/1664980","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:55:39Z","timestamp":1784530539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of Multidrug Resistance Among Gram\u2010Positive Uropathogens in Central Portugal: A 5\u2010Year Retrospective Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7255-9450","authenticated-orcid":false,"given":"Muhammad","family":"Adnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9862-0691","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5045-7477","authenticated-orcid":false,"given":"S\u00f3nia","family":"Mateus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-5912","authenticated-orcid":false,"given":"Miguel Castelo","family":"Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-4249","authenticated-orcid":false,"given":"Francisco","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89240-5"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2020-139090"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2021.05.005"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0870-9025(11)70016-5"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12040623"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74834-y"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.3881\/j.issn.1000-503X.14368"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2024.2389478"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.8059"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S200988"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0328042"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90535-6"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.035"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaf057"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12040778"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00811-8"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.18502\/ijm.v12i5.4599"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract15010014"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract15060100"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/bacteria4010010"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/bacteria5010008"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0259602"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266878"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00276-21"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192416556"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.107605"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08711-0"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.33314\/jnhrc.v20i01.4142"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-025-01125-2"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01688-1"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000001476"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01092-4"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rceng.2020.09.004"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12088-024-01216-7"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2023.09.008"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-025-01958-0"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01822-25"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2021.126772"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00297-5"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2021.101491"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmmb.2024.100732"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11060768"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2016.0318"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0285427"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.14.04184"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53253-x"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116135"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12060973"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2024.106183"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2400108"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-023-02773-5"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2022.12.022"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.19071"},{"key":"e_1_2_13_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-024-05146-7"},{"key":"e_1_2_13_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00367"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-024-04923-7"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.18239"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/asmcr.00085-25"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12071133"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.1017\/ash.2024.437"},{"key":"e_1_2_13_61_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000001057"},{"key":"e_1_2_13_62_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-025-01557-y"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14090855"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871526522666220928115043"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3432"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.08.014"}],"container-title":["International Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijm\/1664980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/ijm\/1664980","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/ijm\/1664980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:55:41Z","timestamp":1784530541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/ijm\/1664980"}},"subtitle":[],"editor":[{"given":"Daniel","family":"Ajose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/ijm\/1664980"],"URL":"https:\/\/doi.org\/10.1155\/ijm\/1664980","archive":["Portico"],"relation":{},"ISSN":["1687-918X","1687-9198"],"issn-type":[{"value":"1687-918X","type":"print"},{"value":"1687-9198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1664980"}}